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      Risk factors and epidemiology of human T-lymphotropic virus types 1 and 2 in US blood donors

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      1 , , 2 , 3 , 2 , 2 , 2 , 4 , 1
      Retrovirology
      BioMed Central
      17th International Conference on Human Retroviruses: HTLV and Related Viruses
      18-21 June 2015

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          Abstract

          Blood donations in the US are routinely screened for markers of human T-lymphotropic virus (HTLV). Seroprevalence and risk factors associated with HTLV-1 and -2 infection from the US Retrovirus Epidemiology Donor Study (REDS-II) Transfusion-Transmitted Viral Infection (TTVI) Rate and Risk Factor Study are reported. Among 14,809,334 blood donations screened during 2011-2012, 516 HTLV confirmed seropositive cases were identified, with an overall prevalence of 3.5 infections per 1,0 donations (95% CI: 3.2-3.8). A case-control study of risk factors from 90 donors with serology-confirmed HTLV-1 infection, 102 with HTLV-2 (cases), and 1,587 donors with false-positive results (controls) was conducted. Frequencies and adjusted odds ratios (AORs) from separate multivariable logistic regression analyses for HTLV-1 and -2 cases compared to controls are reported. Mean age was 48.0 (SD: 12.4), 52.3 (SD: 11.0) and 41.7 (SD: 15.7) years for HTLV-1, HTLV-2 cases and controls, respectively. Being a first-time donor, older, non-white, non-Hispanic female were significant demographic factors associated with both infections. HTLV-1 cases were more likely than controls to be Black (AOR: 13.3, 95% CI: 6.1-29.2), born outside of the US (AOR: 8.6, 95% CI: 4.0-18.4), have migrated (family or self) from an endemic area (AOR: 1.8, 95% CI: 1.2-2.7), report sex with an IDU (AOR: 10.9, 95% CI: 3.6-33.4) or have multiple partners (AOR: 3.1, 95% CI: 1.5-6.1). HTLV-2 cases were more likely to be Black (AOR: 15.4, 95% CI: 6.9-34.3), Native Americans (AOR: 10.7, 95% CI: 1.5-77.0), report sex with an IDU (AOR: 27.2, 95% CI: 9.7-75.8) or have multiple partners (AOR: 2.9, 95% CI: 1.5-5.7). US blood donors with HTLV-1 or -2 infection present with the known risk factors. Migration from endemic areas is mainly associated with HTLV-1 infection, while HTLV-2 is associated with Native American donors. Sexual risk behavior and IDU continue to be risk factors for both viruses.

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          Author and article information

          Conference
          Retrovirology
          Retrovirology
          Retrovirology
          BioMed Central
          1742-4690
          2015
          28 August 2015
          : 12
          : Suppl 1
          : P84
          Affiliations
          [1 ]Blood Systems Research Institute, San Francisco, CA, USA
          [2 ]American Red Cross, Rockville, MD, USA
          [3 ]New York Blood Center, New York, NY, USA
          [4 ]National Heart, Lung and Blood Institute, Bethesda, MD, USA
          Article
          1742-4690-12-S1-P84
          10.1186/1742-4690-12-S1-P84
          4577738
          1e8630a1-0cf2-4991-ac73-360ae458f05e
          Copyright © 2015 Vahidnia et al.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

          17th International Conference on Human Retroviruses: HTLV and Related Viruses
          Trois Ilets, Martinique
          18-21 June 2015
          Categories
          Poster Presentation

          Microbiology & Virology
          Microbiology & Virology

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