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      Stress-induced analgesia

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      Progress in Neurobiology
      Elsevier BV

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          Abstract

          For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia is influenced by age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway. Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the endogenous opioid, monoamine, cannabinoid, gamma-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders.

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          Author and article information

          Journal
          Progress in Neurobiology
          Progress in Neurobiology
          Elsevier BV
          03010082
          July 2009
          July 2009
          : 88
          : 3
          : 184-202
          Article
          10.1016/j.pneurobio.2009.04.003
          19393288
          1e863922-1576-484d-9450-1c4f0a09c0a9
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

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