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      Hippo signaling: growth control and beyond.

      Development (Cambridge, England)

      Protein-Serine-Threonine Kinases, genetics, Signal Transduction, metabolism, physiology, Organ Size, Models, Biological, Mice, Intracellular Signaling Peptides and Proteins, Gene Expression Regulation, Developmental, Drosophila Proteins, Drosophila, Animals

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          Abstract

          The Hippo pathway has emerged as a conserved signaling pathway that is essential for the proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms of signal transduction of the core kinases Hippo/Mst and Warts/Lats are relatively well understood, less is known about the upstream inputs of the pathway and about the downstream cellular and developmental outputs. Here, we review recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development. We also discuss the expanding diversity of Hippo signaling functions during development, discoveries that shed light on a complex regulatory system and provide exciting new insights into the elusive mechanisms that regulate organ growth and regeneration.

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          Author and article information

          Journal
          21138973
          10.1242/dev.045500
          2998162

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