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      Hippo signaling: growth control and beyond.

        1 ,
      Development (Cambridge, England)
      The Company of Biologists

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          Abstract

          The Hippo pathway has emerged as a conserved signaling pathway that is essential for the proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms of signal transduction of the core kinases Hippo/Mst and Warts/Lats are relatively well understood, less is known about the upstream inputs of the pathway and about the downstream cellular and developmental outputs. Here, we review recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development. We also discuss the expanding diversity of Hippo signaling functions during development, discoveries that shed light on a complex regulatory system and provide exciting new insights into the elusive mechanisms that regulate organ growth and regeneration.

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          Author and article information

          Journal
          Development
          Development (Cambridge, England)
          The Company of Biologists
          1477-9129
          0950-1991
          Jan 2011
          : 138
          : 1
          Affiliations
          [1 ] Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. ghalder@mdanderson.org
          Article
          138/1/9
          10.1242/dev.045500
          2998162
          21138973
          1e8ccea0-8b06-48f0-af03-fbe8f2e599ab
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