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      NT-proBNP level before primary PCI and risk of poor myocardial reperfusion: Insight from the On-TIME II trial

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          Most cited references31

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          2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation

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            The therapeutic potential of carbon monoxide.

            Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic molecule with important signalling capabilities in physiological and pathophysiological situations. The endogenous production of CO occurs through the activity of constitutive (haem oxygenase 2) and inducible (haem oxygenase 1) haem oxygenases, enzymes that are responsible for the catabolism of haem. Through the generation of its products, which in addition to CO includes the bile pigments biliverdin, bilirubin and ferrous iron, the haem oxygenase 1 system also has an obligatory role in the regulation of the stress response and in cell adaptation to injury. This Review provides an overview of the physiology of CO, summarizes the effects of CO gas and CO-releasing molecules in preclinical animal models of cardiovascular disease, inflammatory disorders and organ transplantation, and discusses the development and therapeutic options for the exploitation of this simple gaseous molecule.
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              Natriuretic peptides.

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                Author and article information

                Journal
                American Heart Journal
                American Heart Journal
                Elsevier BV
                00028703
                March 2021
                March 2021
                : 233
                : 78-85
                Article
                10.1016/j.ahj.2020.12.017
                1e97db50-b826-48fd-ac36-61a241a4e771
                © 2021

                https://www.elsevier.com/tdm/userlicense/1.0/

                http://creativecommons.org/licenses/by/4.0/

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