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      GH Treatment Induces Sustained Catch-Up Growth in Children with Intrauterine Growth Retardation: 7-Year Results


      Hormone Research in Paediatrics

      S. Karger AG

      Intrauterine growth retardation, Short stature, Growth hormone treatment

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          The anthropometric response to 7 years of GH treatment was assessed in 11 short children with Russell-Silver syndrome (RSS) and in 5 with non-dysmorphic intrauterine growth retardation (NRSS). GH treatment induced a significant increase (p < 0.0001) in the mean height standard deviation score (SDS) and at the 7-year follow-up a height appropriate for the natural history of final stature in NRSS/RSS was already attained. An appreciable growth rate was still present with final height being attained only in 2 girls. There was no significant change in height SDS for bone age. Multiple regression analysis showed only chronological age at the onset of GH treatment was a predictor of gain in height SDS during GH therapy. These findings suggest that early GH treatment improves long-term growth in children with NRSS/RSS. Moreover, final height attainment is required for a definitive assessment of the beneficial effect on adult stature. Bone age assessment is not a reliable parameter to predict final height outcome in these children.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          10 December 2008
          : 48
          : 4
          : 173-177
          Great Ormond Street Hospital for Children, NHS Trust, London, UK
          185509 Horm Res 1997;48:173–177
          © 1997 S. Karger AG, Basel

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          Pages: 5
          Original Paper


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