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      The PAR proteins: fundamental players in animal cell polarization.

      1 , 2
      Developmental cell
      Elsevier BV

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          Abstract

          The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning in the early embryo of C. elegans, and encode six different proteins required for asymmetric cell division by the worm zygote. Some of the PAR proteins are localized asymmetrically and form physical complexes with one another. Strikingly, the PAR proteins have been found to regulate cell polarization in many different contexts in diverse animals, suggesting they form part of an ancient and fundamental mechanism for cell polarization. Although the picture of how the PAR proteins function remains incomplete, cell biology and biochemistry are beginning to explain how PAR proteins polarize cells.

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          Author and article information

          Journal
          Dev Cell
          Developmental cell
          Elsevier BV
          1534-5807
          1534-5807
          Nov 2007
          : 13
          : 5
          Affiliations
          [1 ] Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: bobg@unc.edu.
          [2 ] Department of Microbiology, Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: igm9c@virginia.edu.
          Article
          S1534-5807(07)00385-1 NIHMS34081
          10.1016/j.devcel.2007.10.007
          2964935
          17981131
          1eb5efe3-d453-4ae2-badd-6dbaea28f250
          History

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