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      Immunohistochemical analysis of gamma catenin in Wilms' tumors.

      Fetal and Pediatric Pathology
      Child, Child, Preschool, Desmoplakins, metabolism, Female, Fluorescent Antibody Technique, Direct, Humans, Immunoenzyme Techniques, methods, Infant, Kidney, pathology, Kidney Neoplasms, Lung Neoplasms, secondary, Male, Neoplasm Staging, Tumor Markers, Biological, Wilms Tumor

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          Abstract

          The aim of our study was to investigate the expression of gamma-catenin in normal kidney and in Wilms' tumor by immunohistochemistry and to correlate the results with tumor stage, histological type, and prognostic group. We investigated 28 cases of Wilms' tumor, 2 Wilms' tumor metastases in lungs, and 1 specimen of normal renal tissue. Expression of gamma-catenin was detected in 14 cases. There was a weak inverse relationship between gamma-catenin expression and tumor stage. Expression of gamma-catenin was detected in various histologic types of Wilms' tumor, but there was no statistically significant correlation, except in cases with diffuse anaplasia that were negative. In 2 metastatic cases and in the case of bilateral Wilms' tumor gamma-catenin immunostaining was not observed Our findings suggest an absence of strong correlation between the loss of gamma-catenin and unfavorable outcome.

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