Laura Sandra Lello: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – original draft
Age Utt:
ORCID: http://orcid.org/0000-0002-6709-2507
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
SupervisionRole: ValidationRole: Writing – original draft
Koen Bartholomeeusen: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: SupervisionRole: ValidationRole: Writing – review & editing
Sainan Wang:
ORCID: http://orcid.org/0000-0002-7046-4965
Role: InvestigationRole: Methodology
Kai Rausalu:
ORCID: http://orcid.org/0000-0002-8926-5907
Role: InvestigationRole: Methodology
Catherine Kendall:
ORCID: http://orcid.org/0000-0002-1037-2436
Role: InvestigationRole: Methodology
Sandra Coppens: Role: Investigation
Rennos Fragkoudis: Role: ConceptualizationRole: ResourcesRole: SupervisionRole: Writing – review & editing
Andrew Tuplin:
ORCID: http://orcid.org/0000-0003-2524-707X
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole:
ResourcesRole: Writing – review & editing
Luke Alphey:
ORCID: http://orcid.org/0000-0002-2916-3802
Role: ConceptualizationRole: Funding acquisitionRole: ResourcesRole: Writing – review
& editing
Kevin K. Ariën: Role: ConceptualizationRole: Funding acquisitionRole: ResourcesRole: SupervisionRole:
Writing – review & editing
Andres Merits:
ORCID: http://orcid.org/0000-0001-8193-0071
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: Writing – original draftRole: Writing – review & editing
Thomas E. Morrison: Role: Editor
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
4
September
2020
Publication date Collection:
September
2020
Volume: 16
Issue: 9
Electronic Location Identifier: e1008825
Affiliations
[1
]
Institute of Technology, University of Tartu, Tartu, Estonia
[2
]
Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium
[3
]
Faculty of Biological Sciences and Astbury Centre for Structural and Molecular Biology,
University of Leeds, Leeds, United Kingdom
[4
]
University of Nottingham, School of Veterinary Medicine and Science, Loughborough,
United Kingdom
[5
]
The Pirbright Institute, Woking, United Kingdom
[6
]
Department of Biomedical Sciences, University of Antwerp, Antwerpen, Belgium
University of Colorado Denver, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
[¤]
Current address: Edinburgh Genome Foundry, University of Edinburgh, Edinburgh, United
Kingdom
Author information
Article
Publisher ID:
PPATHOGENS-D-20-00382
DOI: 10.1371/journal.ppat.1008825
PMC ID: 7498090
PubMed ID: 32886709
SO-VID: 1ec07212-d0aa-4072-b6a4-29f5ba6532af
Copyright © © 2020 Lello et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: European Regional Development Fund through the Centre of Excellence in Molecular Cell
Engineering, Estonia
Award ID: 2014-2020.4.01.15-013
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8193-0071
Andres Merits
Funded by: funder-id http://dx.doi.org/10.13039/501100002301, Eesti Teadusagentuur;
Award ID: IUT20-27
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8193-0071
Andres Merits
Funded by: The Wellcome Trust
Award ID: 200171/Z/15/Z
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2916-3802
Luke Alphey
Funded by: Research Foundation Flanders
Award ID: KAN1526318N
Award Recipient
:
Koen Bartholomeeusen
Funded by: Biotechnology and Biological Sciences Research Council (GB)
Award ID: BBS/E/I/00007033, BBS/E/I/00007038 and BBS/E/I/00007039
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2916-3802
Luke Alphey
Funded by: UK Medical Research Council
Award ID: MR/NO1054X/1
Award Recipient
:
ORCID: http://orcid.org/0000-0003-2524-707X
Andrew Tuplin
AM: European Regional Development Fund through the Centre of Excellence in Molecular
Cell Engineering, Estonia [2014-2020.4.01.15-013], institutional research funding
from Estonian Research Council [IUT20-27], The Wellcome Trust [200171/Z/15/Z], Basic
funding from Institute of Technology KB:Research Foundation Flanders (FWO) grant [KAN1526318N]
KKA: intramural research funding. RF:The Wellcome Trust [200171/Z/15/Z] LA: The Wellcome
Trust [200171/Z/15/Z]; core funding from the UK Biotechnology and Biological Sciences
Research Council (BBSRC) to The Pirbright Institute [BBS/E/I/00007033, BBS/E/I/00007038
and BBS/E/I/00007039] AT: UK Medical Research Council (MRC) grant [MR/NO1054X/1].
The funders had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Chikungunya Virus
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Chikungunya Virus
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Chikungunya Virus
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Chikungunya Virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
O'Nyong'Nyong Virus
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
O'Nyong'Nyong Virus
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
O'Nyong'Nyong Virus
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
O'Nyong'Nyong Virus
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Replication
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Transfection
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Transfection
Subject:
Biology and life sciences
Subject:
Molecular biology
Subject:
Macromolecular structure analysis
Subject:
RNA structure
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
RNA
Subject:
RNA structure
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Disease Vectors
Subject:
Insect Vectors
Subject:
Mosquitoes
Subject:
Biology and Life Sciences
Subject:
Species Interactions
Subject:
Disease Vectors
Subject:
Insect Vectors
Subject:
Mosquitoes
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Entomology
Subject:
Insects
Subject:
Mosquitoes
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Invertebrates
Subject:
Arthropoda
Subject:
Insects
Subject:
Mosquitoes
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Invertebrates
Subject:
Arthropoda
Subject:
Insects
Subject:
Mosquitoes
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Microbial Genomics
Subject:
Viral Genomics
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Microbial Genomics
Subject:
Viral Genomics
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Genomics