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      In vivo Secretion of LHRH in Ovariectomized Rats Is Regulated by a Possible Autofeedback Mechanism

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          Abstract

          An episodic secretion of LHRH in pituitary portal blood was observed in ovariectomized and hypophysectomized rats under Saffan anesthesia. This anesthetic did not effect the pulsatile release of LH in ovariectomized rats. Third-ventricular administration of an LHRH agonist, at a concentration which did not cross-react in the LHRH RIA, suppressed both the pulse amplitude and frequency of LHRH release. This inhibitory action of the LHRH agonist on LHRH release was blocked by an LHRH antagonist.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1987
          1987
          02 April 2008
          : 45
          : 6
          : 510-513
          Affiliations
          Department of Reproductive Medicine, School of Medicine, M-025, University of California at San Diego, La Jolla, Calif., USA
          Article
          124783 Neuroendocrinology 1987;45:510–513
          10.1159/000124783
          3302744
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Rapid Communication

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