In vivo Secretion of LHRH in Ovariectomized Rats Is Regulated by a Possible Autofeedback Mechanism

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Abstract

An episodic secretion of LHRH in pituitary portal blood was observed in ovariectomized and hypophysectomized rats under Saffan anesthesia. This anesthetic did not effect the pulsatile release of LH in ovariectomized rats. Third-ventricular administration of an LHRH agonist, at a concentration which did not cross-react in the LHRH RIA, suppressed both the pulse amplitude and frequency of LHRH release. This inhibitory action of the LHRH agonist on LHRH release was blocked by an LHRH antagonist.

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Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1987

Publication date (Print): 1987

Publication date (Electronic): 02 April 2008

Volume: 45

Issue: 6

Pages: 510-513

Affiliations

Department of Reproductive Medicine, School of Medicine, M-025, University of California at San Diego, La Jolla, Calif., USA

Article

Publisher ID: 124783 Other ID: Neuroendocrinology 1987;45:510–513

DOI: 10.1159/000124783

PubMed ID: 3302744

SO-VID: 1ecd145f-b9f5-4948-a079-548e182ac331

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 29 September 1986

Date accepted : 23 February 1987

Page count

Pages: 4

In vivo Secretion of LHRH in Ovariectomized Rats Is Regulated by a Possible Autofeedback Mechanism

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Karger: Endocrinology

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