Acute Effects of Hemodialysis on Erythrocyte Sodium Fluxes in Uremic Patients

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Abstract

The acute effects of both acetate and bicarbonate hemodialysis on erythrocyte transmembrane sodium fluxes were investigated in 15 patients with chronic uremia. We observed a significant (p < 0.0l) stimulation of the Na+, K+ pump in both procedures, with a significant correlation to the amount of fluid removed during hemodialysis (r = 0.56, p < 0.03). Outward Na+ cotransport fluxes significantly rose (p < 0.05) after acetate hemodialysis and decreased (p < 0.05) after bicarbonate hemodialysis. Minor and not significant pre- and posthemodialysis bidirectional changes were observed as regards the intraerythrocyte Na+ and K+ concentration, passive Na+ and K+ permeability, and Na+, Li+ countertransport. Hemodialysis may acutely affect the erythrocyte sodium pump and cotransport fluxes, possibly through the modulation of hormonal factors triggered by the extracellular volume changes.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1985

Publication date (Print): 1985

Publication date (Electronic): 04 December 2008

Volume: 41

Issue: 1

Pages: 22-25

Affiliations

Medical Nephrology, University of Turin; Nephrology and Dialysis Units, S. Giovanni Hospital, Turin, Italy

Article

Publisher ID: 183540 Other ID: Nephron 1985;41:22–25

DOI: 10.1159/000183540

PubMed ID: 2412141

SO-VID: 1ed13ade-2cbd-4d35-8b63-5eece3a6e829

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Acute Effects of Hemodialysis on Erythrocyte Sodium Fluxes in Uremic Patients

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Karger: Nephrology

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