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      Acute Effects of Hemodialysis on Erythrocyte Sodium Fluxes in Uremic Patients

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          The acute effects of both acetate and bicarbonate hemodialysis on erythrocyte transmembrane sodium fluxes were investigated in 15 patients with chronic uremia. We observed a significant (p < 0.0l) stimulation of the Na<sup>+</sup>, K<sup>+</sup> pump in both procedures, with a significant correlation to the amount of fluid removed during hemodialysis (r = 0.56, p < 0.03). Outward Na<sup>+</sup> cotransport fluxes significantly rose (p < 0.05) after acetate hemodialysis and decreased (p < 0.05) after bicarbonate hemodialysis. Minor and not significant pre- and posthemodialysis bidirectional changes were observed as regards the intraerythrocyte Na<sup>+</sup> and K<sup>+</sup> concentration, passive Na<sup>+</sup> and K<sup>+</sup> permeability, and Na<sup>+</sup>, Li<sup>+</sup> countertransport. Hemodialysis may acutely affect the erythrocyte sodium pump and cotransport fluxes, possibly through the modulation of hormonal factors triggered by the extracellular volume changes.

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          Author and article information

          S. Karger AG
          04 December 2008
          : 41
          : 1
          : 22-25
          Medical Nephrology, University of Turin; Nephrology and Dialysis Units, S. Giovanni Hospital, Turin, Italy
          183540 Nephron 1985;41:22–25
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 4
          Original Paper

          Cardiovascular Medicine, Nephrology

          Erythrocyte, Hemodialysis, Uremia, Sodium transport


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