10
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Characterization of Osh3, an oxysterol-binding protein, in filamentous growth of Saccharomyces cerevisiae and Candida albicans.

      Journal of microbiology (Seoul, Korea)
      Candida albicans, genetics, growth & development, Fungal Proteins, physiology, Gene Deletion, Gene Expression Regulation, Fungal, Models, Genetic, Phenotype, Polymerase Chain Reaction, methods, Receptors, Steroid, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription Factors

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          OSH3 is one of the seven yeast homologues of the oxysterol binding proteins (OSBPs) which have the major binding affinity to the oxysterols and function as regulator of cholesterol biosynthesis in mammals. Mutational analysis of OSH3 showed that OSH3 plays a regulatory role in the yeast-to-hyphal transition through its oxysterol-binding domain in Saccharomyces cerevisiae. The OSH3 gene was also identified in the pathogenic yeast Candida albicans. Deletion of OSH3 caused a defect in the filamentous growth, which is the major cause of the C. albicans pathogencity. The filamentation defect of the mutation in the MAPK-associated transcription factor, namely cph1Delta was suppressed by overexpression of OSH3. These findings suggest the regulatory roles of OSH3 in the yeast filamentous growth and the functional conservations of OSH3 in S. cerevisiae and C. albicans.

          Related collections

          Author and article information

          Comments

          Comment on this article