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      Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement.

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          Abstract

          Oxidative stress, an excess of reactive oxygen species (ROS) production versus consumption, may be involved in the pathogenesis of different diseases. The only known enzymes solely dedicated to ROS generation are nicotinamide adenine dinucleotide phosphate (NADPH) oxidases with their catalytic subunits (NOX). After the clinical failure of most antioxidant trials, NOX inhibitors are the most promising therapeutic option for diseases associated with oxidative stress.

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          Author and article information

          Journal
          Antioxid Redox Signal
          Antioxidants & redox signaling
          Mary Ann Liebert Inc
          1557-7716
          1523-0864
          Aug 10 2015
          : 23
          : 5
          Affiliations
          [1 ] Department of Pharmacology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht, the Netherlands .
          Article
          10.1089/ars.2013.5814
          4543484
          24383718
          1ee243aa-314e-4c7b-bfd2-8f007a782e42
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