For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
12
views
106
references
 Top references
cited by
12
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      169
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Biomarkers Associated with the Outcome of Traumatic Brain Injury Patients

      review-article
      Author(s):
      Publication date (Electronic):
      Journal: Brain Sciences
      Publisher: MDPI
      Keywords: biomarkers, prognosis, mortality, traumatic brain injury, caspase-3, total antioxidant capacity, melatonin, malondialdehyde, substance P

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This review focuses on biomarkers associated with the outcome of traumatic brain injury (TBI) patients, such as caspase-3; total antioxidant capacity; melatonin; S100B protein; glial fibrillary acidic protein (GFAP); glutamate; lactate; brain-derived neurotrophic factor (BDNF); substance P; neuron-specific enolase (NSE); ubiquitin carboxy-terminal hydrolase L-1 (UCH-L1); tau; decanoic acid; and octanoic acid.

          Related collections

          Most cited references106

          • Record: found
          • Abstract: not found
          • Article: not found

          Malondialdehyde determination as index of lipid peroxidation.

          H. Draper, M Hadley (1990)
          Article 0 comments Cited 393 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Melatonin as a natural ally against oxidative stress: a physicochemical examination.

            Annia Galano, Dun Tan, Russel Reiter (2011)
            Oxidative stress has been proven to be related to the onset of a large number of health disorders. This chemical stress is triggered by an excess of free radicals, which are generated in cells because of a wide variety of exogenous and endogenous processes. Therefore, finding strategies for efficiently detoxifying free radicals has become a subject of a great interest, from both an academic and practical points of view. Melatonin is a ubiquitous and versatile molecule that exhibits most of the desirable characteristics of a good antioxidant. The amount of data gathered so far regarding the protective action of melatonin against oxidative stress is overwhelming. However, rather little is known concerning the chemical mechanisms involved in this activity. This review summarizes the current progress in understanding the physicochemical insights related to the free radical-scavenging activity of melatonin. Thus far, there is a general agreement that electron transfer and hydrogen transfer are the main mechanisms involved in the reactions of melatonin with free radicals. However, the relative importance of other mechanisms is also analyzed. The chemical nature of the reacting free radical also has an influence on the relative importance of the different mechanisms of these reactions. Therefore, this point has also been discussed in detail in the current review. Based on the available data, it is concluded that melatonin efficiently protects against oxidative stress by a variety of mechanisms. Moreover, it is proposed that even though it has been referred to as the chemical expression of darkness, perhaps it could also be referred to as the chemical light of health. © 2011 John Wiley & Sons A/S.
            Article 0 comments Cited 290 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives.

              José L Mauriz, Pilar Collado, Christiano Veneroso … (2013)
              Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced by the pineal gland, but also by other nonendocrine organs, of most mammals including man. In the recent years, a variety of anti-inflammatory and antioxidant effects have been observed when melatonin is applied exogenously under both in vivo and in vitro conditions. A number of studies suggest that this indole may exert its anti-inflammatory effects through the regulation of different molecular pathways. It has been documented that melatonin inhibits the expression of the isoforms of inducible nitric oxide synthase and cyclooxygenase and limits the production of excessive amounts of nitric oxide, prostanoids, and leukotrienes, as well as other mediators of the inflammatory process such as cytokines, chemokines, and adhesion molecules. Melatonin's anti-inflammatory effects are related to the modulation of a number of transcription factors such as nuclear factor kappa B, hypoxia-inducible factor, nuclear factor erythroid 2-related factor 2, and others. Melatonin's effects on the DNA-binding capacity of transcription factors may be regulated through the inhibition of protein kinases involved in signal transduction, such as mitogen-activated protein kinases. This review summarizes recent research data focusing on the modulation of the expression of different inflammatory mediators by melatonin and the effects on cell signaling pathways responsible for the indole's anti-inflammatory activity. Although there are a numerous published reports that have analyzed melatonin's anti-inflammatory properties, further studies are necessary to elucidate its complex regulatory mechanisms in different cellular types and tissues. © 2012 John Wiley & Sons A/S.
              Article 0 comments Cited 178 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Brain Sci
                Journal ID (iso-abbrev): Brain Sci
                Journal ID (publisher-id): brainsci
                Title: Brain Sciences
                Publisher: MDPI
                ISSN (Electronic): 2076-3425
                Publication date (Electronic): 27 October 2017
                Publication date Collection: November 2017
                Volume: 7
                Issue: 11
                Electronic Location Identifier: 142
                Affiliations
                Intensive Care Unit, Hospital Universitario de Canarias, La Laguna, Santa Cruz de Tenerife 38320, Spain; lorentemartin@ 123456msn.com ; Tel.: +34-922-678-000
                Author information
                https://orcid.org/0000-0003-4902-4065
                Article
                Publisher ID: brainsci-07-00142
                DOI: 10.3390/brainsci7110142
                PMC ID: 5704149
                PubMed ID: 29076989
                SO-VID: 1ee398fd-8eb1-4182-a253-4fb10042d220
                Copyright © © 2017 by the author.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 29 August 2017
                Date accepted : 20 October 2017
                Categories
                Subject: Review

                Keywords: biomarkers,prognosis,mortality,traumatic brain injury,caspase-3,total antioxidant capacity,melatonin,malondialdehyde,substance p
                Data availability:
                Keywords: biomarkers, prognosis, mortality, traumatic brain injury, caspase-3, total antioxidant capacity, melatonin, malondialdehyde, substance p

                Comments

                Comment on this article

                scite_

                Similar content169

                See all similar

                Cited by12

                See all cited by

                Most referenced authors1,527

                See all reference authors