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Inhibitory effect of adenosine on intimal hyperplasia and proliferation of smooth muscle cells in a carotid arterial anastomosis animal model

Author(s): Gokhan Albayrak ¹ , Erdem Silistreli ² , Bekir Ergur ³ , Sule Kalkan ⁴ , Ozalp Karabay ² , A Cenk Erdal ² , Unal Acikel ⁵

Publication date Created: May 29 2014

Publication date (Electronic): May 06 2014

Journal: Vascular

Publisher: SAGE Publications

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Abstract

The effect of adenosine (9-β-0-ribifuranosyladenine) on the endothelial cell proliferation and neointimal hyperplasia is investigated in the rabbit carotid artery anastomosis model.

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Most cited references 17

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Structure and function of adenosine receptors and their genes.

B Kull, L Halldner, G Arslan … (2000)

Four adenosine receptors have been cloned from many mammalian and some non-mammalian species. In each case the translated part of the receptor is encoded by two separate exons. Two separate promoters regulate the A1 receptor expression, and a similar situation may pertain also for the other receptors. The receptors are expressed in a cell and tissue specific manner, even though A1 and A2B receptors are found in many different cell types. Emerging data indicate that the receptor protein is targeted to specific parts of the cell. A1 and A3 receptors activate the Gi family of G proteins, whereas A2A and A2B receptors activate the Gs family. However, other G proteins can also be activated even though the physiological significance of this is unknown. Following the activation of G proteins several cellular effector pathways can be affected. Signaling via adenosine receptors is also known to interact in functionally important ways with signaling initiated via other receptors.

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Intimal hyperplasia in vascular grafts.

J Tordoir, P Kitslaar, M Susan Lemson … (2000)

0 comments Cited 36 times – based on 0 reviews      Review now

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Aortocoronary Saphenous Vein Graft Disease

Joseph Motwani, Eric Topol, J. Motwani … (1998)

0 comments Cited 22 times – based on 0 reviews      Review now

Author and article information

Journal

Title: Vascular

Abbreviated Title: Vascular

Publisher: SAGE Publications

ISSN (Print): 1708-5381

ISSN (Electronic): 1708-539X

Publication date Created: May 29 2014

Publication date Created: April 2015

Publication date (Electronic): May 06 2014

Publication date (Print): April 2015

Volume: 23

Issue: 2

Pages: 124-131

Affiliations

[1 ]Department of Cardiovascular Surgery, Izmir University, Medical Park Hospital, Izmir, Turkey

[2 ]Department of Cardiovascular Surgery, Dokuz Eylul University, School of Medicine, Izmir, Turkey

[3 ]Department of Histology and Embriology, Dokuz Eylul University, School of Medicine, Izmir, Turkey

[4 ]Department of Pharmacology, Dokuz Eylul University, School of Medicine, Izmir, Turkey

[5 ]Department of Cardiovascular Surgery, Private Ege Hospital, Denizli, Turkey

Article

DOI: 10.1177/1708538114533962

PubMed ID: 24803551

SO-VID: 1ee3cf4e-b34a-4ccc-be39-ab425d50c815

Copyright © © 2015

License:

http://journals.sagepub.com/page/policies/text-and-data-mining-license

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