α<sub>1</sub>-Adrenoreceptor affinity constants (K<sub>D</sub>) and receptor numbers( B<sub>max</sub>) were determined in the kidneys of 3-day-old bile-duct-ligated (BDL) jaundiced rats using <sup>3</sup>H-prazosin. The results were compared to 3-day-old pair-fed and nonpair-fed sham-operated rats as well as nonoperated rats as controls. Abdominal surgery (sham and BDL) resulted in a tendency towards a decrease in K<sub>D</sub> in all three groups of rats compared to nonoperated controls. The B<sub>max</sub> was also increased in the sham-operated groups compared to the nonoperated controls. In contrast, the tendency for a rise in the B<sub>max</sub> in the BDL group was significantly smaller than the rise seen in the two sham-operated groups. In summary, obstructive jaundice suppresses the normal renal α<sub>r</sub>adrenoreceptor response to abdominal surgery in the rat.