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      Flow and thrombosis at orifices simulating mechanical heart valve leakage regions.

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          Abstract

          While it is established that mechanical heart valves (MHVs) damage blood elements during leakage and forward flow, the role in thrombus formation of platelet activation by high shear flow geometries remains unclear. In this study, continuously recalcified blood was used to measure the effects of blood flow through orifices, which model MHVs, on the generation of procoagulant thrombin and the resulting formation of thrombus. The contribution of platelets to this process was also assessed.

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          Author and article information

          Journal
          J Biomech Eng
          Journal of biomechanical engineering
          ASME International
          0148-0731
          0148-0731
          Feb 2006
          : 128
          : 1
          Affiliations
          [1 ] School of Chemical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
          Article
          10.1115/1.2133768
          16532615
          1ef30513-0c66-4434-81bb-288a46e92f21
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