5-HT4 receptors contribute to the motor stimulating effect of levosulpiride in the guinea-pig gastrointestinal tract.

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Abstract

The dopamine D2 receptor antagonist levosulpiride is a substituted benzamide derivative, whose gastrokinetic properties are exploited clinically for the management of functional dyspepsia. However, for other benzamide derivatives, such as cisapride and mosapride, agonism towards serotonin 5-HT4 receptors is considered the main mechanism leading to gastrointestinal prokinesia.

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Journal

Journal ID (iso-abbrev): Dig Liver Dis

Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

ISSN: 1590-8658

ISSN (Print): 1590-8658

Publication date (Electronic): Apr 2003

Volume: 35

Issue: 4

Affiliations

[1 ] Department of Physiological and Pharmacological Sciences, University of Pavia, Piazza Botta 10/11, 27100 Pavia, Italy. marcello.tonini@unipv.it

Article

Publisher Item ID: S1590-8658(03)00061-6

PubMed ID: 12801035

SO-VID: 1ef8f7ea-1037-45b0-9974-d3f97e26137b

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