Are Platelet Cytosolic Free Calcium, Serotonin Concentration and Blood Viscosity Different between Hypertensive and Normotensive Subjects?

Abstract

In this study, the platelet intracellular calcium and serotonin (5-HT) concentrations as well as the hemorheological properties were compared in 65 hypertensive (HT) and 25 age-matched normotensive (NT) subjects. The result showed that the platelet intracellular calcium concentration in the HT group was significantly higher than in the NT group (165.4 ± 12.6 vs. 118.9 ± 12.4 nM, p < 0.05). However, the platelet 5-HT content in the HT group was significantly lower than in the NT group (0.28 ± 0.03 vs. 0.38 ± 0.03 nmol/10⁸ platelets, p < 0.05). Moreover, red cell flexibility, red cell deformability, hematocrit, fibrinogen concentration and plasma viscosity were all significantly increased in HT subjects. The whole blood viscosity was generally higher in the HT group. In conclusion, the higher platelet intracellular calcium and lower 5-HT level as well as abnormality of hemorheological properties may be important factors in the initiation and perpetuation of hypertension.

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1994

Publication date (Print): 1994

Publication date (Electronic): 18 November 2008

Volume: 85

Issue: 2

Pages: 76-81

Affiliations

^aDepartment of Medicine and ^bGraduate Institute of Life Sciences, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC

Article

Publisher ID: 176650 Other ID: Cardiology 1994;85:76–81

DOI: 10.1159/000176650

PubMed ID: 7954566

Copyright statement: © 1994 S. Karger AG, Basel

License:

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Page count

Pages: 6

Product

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Categories

Subject: General Cardiology