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Preparation of Quantum Dot/Drug Nanoparticle Formulations for Traceable Targeted Delivery and Therapy

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      Abstract

      Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recent advancement in making biocompatible QD formulations has made these nanocrystals suitable for in vivo applications. This review provides an overview of the preparation of QDs and their use as probes or carriers for traceable, targeted therapy of diseases in vitro and in vivo. More specifically, recent advances in the integration of QDs with drug formulations for therapy and their potential toxicity in vitro and in vivo are highlighted. The current findings and challenges for optimizing QD/drug formulations with respect to optimal size and stability, short-term and long-term toxicity, and in vivo applications are described. Lastly, we attempt to predict key trends in QD/drug formulation development over the next few years and highlight areas of therapy where their use may provide breakthrough results in the near future.

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      Most cited references 95

      • Record: found
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      • Article: not found

      Quantum dots for live cells, in vivo imaging, and diagnostics.

      Research on fluorescent semiconductor nanocrystals (also known as quantum dots or qdots) has evolved over the past two decades from electronic materials science to biological applications. We review current approaches to the synthesis, solubilization, and functionalization of qdots and their applications to cell and animal biology. Recent examples of their experimental use include the observation of diffusion of individual glycine receptors in living neurons and the identification of lymph nodes in live animals by near-infrared emission during surgery. The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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        • Record: found
        • Abstract: found
        • Article: not found

        Semiconductor nanocrystals as fluorescent biological labels.

         M Bruchez,  M Moronne,  P Gin (1998)
        Semiconductor nanocrystals were prepared for use as fluorescent probes in biological staining and diagnostics. Compared with conventional fluorophores, the nanocrystals have a narrow, tunable, symmetric emission spectrum and are photochemically stable. The advantages of the broad, continuous excitation spectrum were demonstrated in a dual-emission, single-excitation labeling experiment on mouse fibroblasts. These nanocrystal probes are thus complementary and in some cases may be superior to existing fluorophores.
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          • Record: found
          • Abstract: not found
          • Article: not found

          Chemistry and properties of nanocrystals of different shapes.

            Bookmark

            Author and article information

            Affiliations
            1. School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore
            2. Department of Chemistry, University of Delhi, Delhi-110 007, India
            3. Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260-4200
            4. Institute for Lasers, Photonics and Biophotonics (ILPB), The State University of New York at Buffalo, Buffalo, NY14260, United States
            5. Division of Chemical and Biomolecular Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459
            6. Institute of Gerontology and Geriatrics, Chinese PLA General Hospital, P. R. China
            7. Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University at Buffalo, The State University of New York, and Kaleida Health, Buffalo, New York, 14203, USA
            Author notes
            ✉ Corresponding author: Dr. Ken-Tye Yong, School of Electrical & Electronic Engineering, Nanyang Technological University, 639798, Singapore. Email: ktyong@ 123456ntu.edu.sg .

            Competing Interests: The authors have declared that no competing interest exists.

            Journal
            Theranostics
            Theranostics
            thno
            Theranostics
            Ivyspring International Publisher (Sydney )
            1838-7640
            2012
            27 July 2012
            : 2
            : 7
            : 681-694
            3418929
            22896770
            10.7150/thno.3692
            thnov02p0681
            © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
            Categories
            Review

            Molecular medicine

            targeted delivery, drug nanoparticle formulations, quantum dots

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