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      Coordinated regulation of myeloid cells by tumours.

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          Abstract

          Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and are a collection of distinct cell populations with many diverse functions. The three groups of terminally differentiated myeloid cells - macrophages, dendritic cells and granulocytes - are essential for the normal function of both the innate and adaptive immune systems. Mounting evidence indicates that the tumour microenvironment alters myeloid cells and can convert them into potent immunosuppressive cells. Here, we consider myeloid cells as an intricately connected, complex, single system and we focus on how tumours manipulate the myeloid system to evade the host immune response.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1741
          1474-1733
          Mar 22 2012
          : 12
          : 4
          Affiliations
          [1 ] H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33647, USA. dmitry.gabrilovich@ moffitt.org
          Article
          nri3175 NIHMS442658
          10.1038/nri3175
          3587148
          22437938
          1f11e1d1-649b-4709-99d3-b218dbc73ad0
          History

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