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      Silver nanoparticles: synthesis, properties, and therapeutic applications.

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          Abstract

          Silver nanoparticles (AgNPs) have been widely used in biomedical fields because of their intrinsic therapeutic properties. Here, we introduce methods of synthesizing AgNPs and discuss their physicochemical, localized surface plasmon resonance (LSPR) and toxicity properties. We also review the impact of AgNPs on human health and the environment along with the underlying mechanisms. More importantly, we highlight the newly emerging applications of AgNPs as antiviral agents, photosensitizers and/or radiosensitizers, and anticancer therapeutic agents in the treatment of leukemia, breast cancer, hepatocellular carcinoma, lung cancer, and skin and/or oral carcinoma.

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          Author and article information

          Journal
          Drug Discov. Today
          Drug discovery today
          1878-5832
          1359-6446
          May 2015
          : 20
          : 5
          Affiliations
          [1 ] School of Pharmacy, Weifang Medical University, Weifang 261053, People's Republic of China; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
          [2 ] Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
          [3 ] Department of Physics, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
          [4 ] Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
          [5 ] Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA. Electronic address: chenz@stjohns.edu.
          [6 ] Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA. Electronic address: gfchen08@yahoo.com.
          Article
          S1359-6446(14)00468-1 NIHMS651778
          10.1016/j.drudis.2014.11.014
          4433816
          25543008
          1f137161-f7a8-4968-9138-f592481f1779
          Copyright © 2014 Elsevier Ltd. All rights reserved.
          History

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