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      Empfehlungen der zweiten Aktualisierung der Leitlinie LONTS : Langzeitanwendung von Opioiden bei chronischen nicht-tumorbedingten Schmerzen Long-term opioid therapy for chronic noncancer pain Translated title: Recommendations of the second update of the LONTS guidelines

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          Abstract

          <p class="first" id="d5582342e228">The second scheduled update of the German S3 guidelines on long-term opioid therapy for chronic noncancer pain (CNCP), the LONTS (AWMF registration number 145/003), was started in December 2018. </p>

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          Diagnostic and Statistical Manual of Mental Disorders

          American Psychiatric Association (2013)
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            CDC Guideline for Prescribing Opioids for Chronic Pain--United States, 2016.

            Deborah Dowell, Tamara Haegerich, Roger Chou (2016)
            Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious risks, including opioid use disorder and overdose.
            Article 0 comments Cited 604 times – based on 0 reviews     Review now
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              Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations.

              Robert H Dworkin, Dennis C Turk, Kathleen Wyrwich … (2008)
              A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical importance of treatment outcomes in clinical trials of the efficacy and effectiveness of chronic pain treatments. A group of 40 participants from universities, governmental agencies, a patient self-help organization, and the pharmaceutical industry considered methodologic issues and research results relevant to determining the clinical importance of changes in the specific outcome measures previously recommended by IMMPACT for 4 core chronic pain outcome domains: (1) Pain intensity, assessed by a 0 to 10 numerical rating scale; (2) physical functioning, assessed by the Multidimensional Pain Inventory and Brief Pain Inventory interference scales; (3) emotional functioning, assessed by the Beck Depression Inventory and Profile of Mood States; and (4) participant ratings of overall improvement, assessed by the Patient Global Impression of Change scale. It is recommended that 2 or more different methods be used to evaluate the clinical importance of improvement or worsening for chronic pain clinical trial outcome measures. Provisional benchmarks for identifying clinically important changes in specific outcome measures that can be used for outcome studies of treatments for chronic pain are proposed. Systematically collecting and reporting the recommended information needed to evaluate the clinical importance of treatment outcomes of chronic pain clinical trials will allow additional validation of proposed benchmarks and provide more meaningful comparisons of chronic pain treatments.
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                Author and article information

                Journal
                Title: Der Schmerz
                Abbreviated Title: Schmerz
                Publisher: Springer Science and Business Media LLC
                ISSN (Print): 0932-433X
                ISSN (Electronic): 1432-2129
                Publication date Created: June 2020
                Publication date (Electronic): May 06 2020
                Publication date (Print): June 2020
                Volume: 34
                Issue: 3
                Pages: 204-244
                Article
                DOI: 10.1007/s00482-020-00472-y
                PubMed ID: 32377861
                SO-VID: 1f26f09b-17fe-4786-8774-ae9ec423cbb8
                Copyright © © 2020
                License:

                Free to read

                http://www.springer.com/tdm

                http://www.springer.com/tdm

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