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      Antihypertensive Effect of Tiapamil, a Calcium Antagonist

      a , b

      Cardiology

      S. Karger AG

      Tiapamil, Ro 11-1781, Calcium antagonist, Arterial hypertension

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          Abstract

          The antihypertensive effects of intravenously and orally administered tiapamil and placebo were compared in 6 male patients (60 ± 5 years; mean ± SD) with mild essential hypertension (WHO classification Stage I) in a randomized double-blind crossover procedure. In the intravenous study, 1 mg/kg loading dose of tiapamil (or placebo) was followed by 50 µg/kg/min tiapamil or placebo over 2 h. In the oral study, the patients received placebo or approximately 6 mg/kg tiapamil. Blood pressure (BP) was determined by the Hawksley Random Zero Sphygmomanometer. Heart rate (HR) and P-R interval were derived from ECGs. Statistical significance was assessed by the paired Student’s t test. While intravenously administered placebo transiently increased both BP and HR, intravenous tiapamil significantly (p v≤ 0.05) lowered both variables. The P-R interval was also transiently but significantly (p ≤ 0.05) increased by intravenous tiapamil. Similarly, orally administered tiapamil showed an antihypertensive effect which was not observed with placebo. Neither HR nor P-R interval was influenced by oral tiapamil. The results suggest that tiapamil is an effective but short-acting antihypertensive agent.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-3588-5
          978-3-318-01756-4
          0008-6312
          1421-9751
          1982
          1982
          07 November 2008
          : 69
          : Suppl 1
          : 99-104
          Affiliations
          aCardiological Division, Department of Clinical Research, F. Hoffmann-La Roche & Co. Ltd., Basel, Switzerland; bDepartment of Internal Medicine, Ospedale Civile di Edolo, Brescia, Italy
          Article
          173543 Cardiology 1982;69:99–104
          10.1159/000173543
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Hemodynamic Effect

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