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      Left Ventricular Dysfunction during Dynamic Exercise in Noninsulin-Dependent Diabetic Patients with Retinopathy

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          Abstract

          Systolic time intervals were obtained from 19 middle-aged noninsulin-dependent diabetic patients without clinically evident cardiovascular disease (8 patients had and 11 did not have retinopathy) and 14 normal subjects using ear densitography. All subjects had neither ischemic electrocardiographic response nor chest pain during maximal treadmill exercise. Although left ventricular ejection time (LVET) and preejection period (PEP) did not differ significantly at rest between the three groups, a prolongation of LVET with a nearly identical PEP response was observed during exercise in diabetic patients with retinopathy. These data indicate that the diabetic patients with retinopathy relied on the enhanced ventricular filling in maintaining stroke volume during exercise. Thus, retinopathy is associated with impaired left ventricular systolic function in noninsulin-dependent diabetic patients.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1991
          1991
          12 November 2008
          : 78
          : 1
          : 23-30
          Affiliations
          The Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan
          Article
          174761 Cardiology 1991;78:23–30
          10.1159/000174761
          2021962
          © 1991 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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