Correction: Phenotypic and Genotypic Characteristics of Novel Mouse Cell Line (NIH/3T3)-Adapted Human Enterovirus 71 Strains (EV71:TLLm and EV71:TLLmv)

Abstract

There are errors in Table 3. Please see the corrected Table 3 here. 10.1371/journal.pone.0092719.t003 Table 3 Adaptive mutations observed in the 5'UTR and P1 regions of EV71:TLLm and EV71:TLLmv viral genomes. EV71:BS vs EV71:TLLm EV71:BS vs EV71:TLLmv Amino acid changes Amino acid changes Genome region Nucleotide changes Polyprotein1 Mature protein2 Genome region Nucleotide changes Polyprotein6 Mature protein7 Cloverleaf Cloverleaf C 140 G IRES 3 A 141 G IRES A 141 C G 195 C T 209 C T 209 C G 258 A G 258 A C 370 T C 370 T Not applicable G 448 A Not applicable G 448 A A 502 C T 502 C G 675 T C 709 T T 677 C A 671 T C 687 T G 675 T C 709 T T 678 INS4 678-681 INS 726-745 DEL5 VP4 A 809 G E 21 G E 21 G VP4 A 809 G E 21 G E 21 G VP2 G 1359 A V 204 I V 135 I VP2 G 1359 A V 204 I V 135 I G 1385 C S 213 T S 144 T G 1385 C S 213 T S 144 T A 1400 T K 218 I K 149 I A 1400 T K 218 I K 149 I T 1428 C E 228 P E 159 P G 1429 C E 228 P E 159 P VP3 G 1900 C A 385 P A 62 P A 2287 G T 514 A T 191 A A 2421 G I 558 M I 235 M VP1 T 2462 C V 572 A V 7 A VP1 T 2462 C V 572 A V 7 A C 2725 T L 660 F L 95 F C 2530 A Q 595 K Q 30 K A 2734 G K 663 E K 98 E A 2719 G I 658 V I 93 V A 2752 G N 669 D N 104 D T 2724 A D 659 E D 94 E A 2876 C E 710 A E 145 A C 2725 T L 660 F L 95 F A 2943 T E 732 D E 167 D A 2734 G K 663 E K 98 E C 2947 T L 734 F L 169 F A 2752 G C 3165 T S 806 L S 241 L A 2753 G N 669 G N 104 G A 2876 C E 710 A E 145 A A 2943 T E 732 D E 167 D C 2947 T L 734 F L 169 F C 3165 T S 806 L S 241 L T 3175 C Y 810 H Y 245 H G 3184 A V 813 I V 248 I G 3319 T A 858 S A 293 S 1 Numbering of amino acids in the uncleaved polyprotein prior to maturation. 2 Numbering of amino acids in the mature protein. 3 IRES - Internal Ribosome Entry Site. 4 INS – Insertion. 5 DEL – Deletion. There are errors in Table 4. Please see the corrected Table 4 here. 10.1371/journal.pone.0092719.t004 Table 4 Adaptive mutations observed in the P2 and P3 regions of EV71:TLLm and EV71:TLLmv viral genomes. EV71:BS vs EV71:TLLm6 EV71:BS vs EV71:TLLmv11 Amino acid changes Amino acid changes Genome region Nucleotide changes Polyprotein7 Mature protein 8 Genome region Nucleotide changes Polyprotein Mature protein 2A G 3722 A G 992 E G 130 E 2A G 3722 A G 992 E G 130 E 2C A 4366 G T 1207 A T 96 A 2C A 4366 G T 1207 A T 96 A 3A C 5117 T A 1457 V A 17 V 3B T 5357 C L 1537 P L 11 P 3B T 5357 C L 1537 P L 11 P 3C A 5557 G I 1604 V I 56 V 3C A 5557 G I 1604 V I 56 V A 5569 G I 1608 V I 60 V A 5569 G I 1608 V I 60 V 3D A 6211 G N 1822 D N 91 D 3D A 6070 T T 1775 S T 44 S9 T 6835 A S 2030 T S 299 T4 T 6137 C V 1797 A V 66 A3 A 7128 T R 2127 S R 396 S5 A 6211 G N 1822 D N 91 D T 7247 C V 2167 A V 436 A5 C 6404 G S 1886 C S 155 C T 6592 G W 1949 G W 218 G10 T 6835 A S 2030 T S 299 T4 A 7128 T R 2127 S R 396 S11 T 7247 C V 2167 A V 436 A5 6 Mutations are based on alignment with the reference EV71:BS genome. 7 Numbering of amino acids in the uncleaved polyprotein prior to maturation. 8 Numbering of amino acids in the mature protein. 9 Mutation located in the Ring finger domain of the RNA-dependent RNA Polymerase. 10 Mutation located in the Palm domain of the RNA-dependent RNA Polymerase. 11 Mutation located in the Thumb domain of the RNA-dependent RNA Polymerase.