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      Autosomal dominant polycystic kidney disease.

      Lancet

      Renal Replacement Therapy, physiopathology, genetics, complications, Polycystic Kidney, Autosomal Dominant, etiology, Pain, Male, physiology, metabolism, anatomy & histology, Kidney Tubules, therapy, epidemiology, Kidney Failure, Chronic, Incidence, Humans, Genotype, Female, Cardiovascular Diseases, Animals

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          Abstract

          Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. An increased understanding of the disorder's underlying genetic, molecular, and cellular mechanisms and a better appreciation of its progression and systemic manifestations have laid out the foundation for the development of clinical trials and potentially effective treatments.

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          Journal
          10.1016/S0140-6736(07)60601-1
          17434405

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