7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Dopamine and Renal Function and Blood Pressure Regulation

      1 , 1 , * , 1

      Comprehensive Physiology

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Dopamine is an important regulator of systemic blood pressure via multiple mechanisms. It affects fluid and electrolyte balance by its actions on renal hemodynamics and epithelial ion and water transport and by regulation of hormones and humoral agents. The kidney synthesizes dopamine from circulating or filtered l-DOPA independently from innervation. The major determinants of the renal tubular synthesis/release of dopamine are probably sodium intake and intracellular sodium. Dopamine exerts its actions via two families of cell surface receptors, D 1-like receptors comprising D 1R and D 5R, and D 2-like receptors comprising D 2R, D 3R, and D 4R, and by interactions with other G protein-coupled receptors. D 1-like receptors are linked to vasodilation, while the effect of D 2-like receptors on the vasculature is variable and probably dependent upon the state of nerve activity. Dopamine secreted into the tubular lumen acts mainly via D 1-like receptors in an autocrine/paracrine manner to regulate ion transport in the proximal and distal nephron. These effects are mediated mainly by tubular mechanisms and augmented by hemodynamic mechanisms. The natriuretic effect of D 1-like receptors is caused by inhibition of ion transport in the apical and basolateral membranes. D 2-like receptors participate in the inhibition of ion transport during conditions of euvolemia and moderate volume expansion. Dopamine also controls ion transport and blood pressure by regulating the production of reactive oxygen species and the inflammatory response. Essential hypertension is associated with abnormalities in dopamine production, receptor number, and/or posttranslational modification.

          Related collections

          Author and article information

          Journal
          101574442
          40016
          Compr Physiol
          Compr Physiol
          Comprehensive Physiology
          2040-4603
          28 December 2018
          July 2011
          22 January 2019
          : 1
          : 3
          : 1075-1117
          Affiliations
          [1 ]Children’s National Medical Center—Center for Molecular Physiology Research, Washington, District of Columbia
          Author notes
          [* ]Correspondence to pjose@ 123456cnmc.org
          Article
          PMC6342207 PMC6342207 6342207 nihpa843291
          10.1002/cphy.c100032
          6342207
          23733636
          Categories
          Article

          Comments

          Comment on this article