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Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial
James F Howard ,
Vera Bril ,
Tuan Vu ,
Chafic Karam ,
Stojan Peric ,
Temur Margania ,
Hiroyuki Murai ,
Malgorzata Bilinska ,
Roman Shakarishvili ,
Marek Smilowski ,
Antonio Guglietta ,
Peter Ulrichts ,
Tony Vangeneugden ,
Kimiaki Utsugisawa ,
Jan Verschuuren ,
Renato Mantegazza ,
Jan L. De Bleecker ,
Kathy De Koning ,
Katrien De Mey ,
Annelien De Pue ,
Rudolf Mercelis ,
Maren Wyckmans ,
Caroline Vinck ,
Linda Wagemaekers ,
Jonathan Baets ,
Eduardo Ng ,
Jafar Shabanpour ,
Lubna Daniyal ,
Shabber Mannan ,
Hans D. Katzberg ,
Angela Genge ,
Zaeem Siddiqi ,
Jana Junkerová ,
Jana Horakova ,
Katerina Reguliova ,
Michaela Tyblova ,
Ivana Jurajdova ,
Iveta Novakova ,
Michala Jakubikova ,
Jiri Pitha ,
Stanislav Vohanka ,
Katerina Havelkova ,
Tomas Horak ,
Josef Bednarik ,
Mageda Horakova ,
Andreas Meisel ,
Dike Remstedt ,
Claudia Heibutzki ,
Siegfried Kohler ,
Lea Gerischer ,
Sarah Hoffman ,
Frauke Stascheit ,
John Vissing ,
Lizzie Zafirakos ,
Kuldeep Kumar Khatri ,
Anne Autzen ,
Mads Peter Godtfeldt Stemmerik ,
Henning Andersen ,
Shahram Attarian ,
Emmanuelle Salort-Campana ,
Emilien Delmont ,
Aude-Marie Grapperon ,
Ludivine Kouton ,
Alexander Tsiskaridze ,
Csilla Rózsa ,
Gedeonne Margo Jakab ,
Szilvia Toth ,
Gyorgyi Szabo ,
David Bors ,
Eniko Szabo ,
Angela Campanella ,
Fiammetta Vanoli ,
Rita Frangiamore ,
Carlo Antozzi ,
Silvia Bonanno ,
Lorenzo Maggi ,
Riccardo Giossi ,
Francesco Saccà ,
Angela Marsili ,
Chiara Pane ,
Giorgia Puorro ,
Antonio Reia ,
Giovanni Antonini ,
Girolamo Alfieri ,
Stefania Morino ,
Matteo Garibaldi ,
Laura Fionda ,
Luca Leonardi ,
Shingo Konno ,
Akiyuki Uzawa ,
Kaoru Sakuma ,
Chiho Watanabe ,
Yukiko Ozawa ,
Manato Yasuda ,
Yosuke Onishi ,
Makoto Samukawa ,
Tomoko Tsuda ,
Yasushi Suzuki ,
Sayaka Ishida ,
Genya Watanabe ,
Masanori Takahashi ,
Hiroko Nakamura ,
Erina Sugano ,
Tomoya Kubota ,
Tomihiro Imai ,
Mari Suzuki. ,
Ayako Mori ,
Daisuke Yamamoto ,
Kazuna Ikeda ,
Shin Hisahara ,
Masayuki Masuda ,
Miki Takaki ,
Kanako Minemoto ,
Nobuhiro Ido ,
Makiko Naito ,
Yoshihiko Okubo ,
Takamichi Sugimoto ,
Yuka Takematsu ,
Ayumi Kamei ,
Mihiro Shimizu ,
Hiroyuki Naito ,
Eiichi Nomura ,
Marjolein Van Heur ,
Anne-Marie Peters ,
Martijn Tannemaat ,
Annabel Ruiter ,
Kevin Keene ,
Marek Halas ,
Andrzej Szczudlik ,
Marta Pinkosz ,
Monika Frasinska ,
Grazyna Zwolinska ,
Anna Kostera-Pruszczyk ,
Aleksandra Golenia ,
Piotr Szczudlik ,
Lech Szczechowski ,
Aneta Pasko ,
Irina Poverennova ,
Lubov Urtaeva ,
Nadezhda Kuznetsova ,
Tatiana Romanova ,
Malkova Nadezhda ,
Elena Lapochka ,
Denis Korobko ,
Ilona Vergunova ,
Anna Melnikova ,
Ekaterina Bulatova ,
Elena Antipenko ,
Ivana Basta ,
Ivo Bozovic ,
Dragana Lavrnic ,
Vidosava Rakocevic Stojanovic ,
Said Beydoun ,
Salma Akhter ,
Ali Malekniazi ,
Leila Darki ,
Norianne Pimentel ,
Victoria Cannon ,
Manisha Chopra ,
Rebecca Traub ,
Tahseen Mozaffar ,
Isela Hernandez ,
Ivonne Turner ,
Ali Habib ,
Namita Goyal ,
Manisha Kak ,
Erik Velasquez ,
Lucy Lam ,
Niraja Suresh ,
Jerrica Farias ,
Sarah Jones ,
Mary Wagoner ,
Debbie Eggleston ,
Tulio Bertorini ,
Cindy Benzel ,
Robert Henegar ,
Rekha Pillai ,
Ratna Bharavaju-Sanka ,
Carolyn Paiz ,
Carlayne Jackson ,
Katherine Ruzhansky ,
Diana Dimitrova ,
Amy Visser ,
Nizar Chahin ,
Todd Levine ,
Robert Lisak ,
Kelly Jia ,
Flicia Mada ,
Evanthia Bernitsas ,
Mamatha Pasnoor ,
Katherine Roath ,
Samantha Colgan ,
Melissa Currence ,
Andrew Heim ,
Richard Barohn ,
Mazen Dimachkie ,
Jeffrey Statland ,
Omar Jawdat ,
Duaa Jabari ,
Constantine Farmakidis ,
James Gilchrist ,
Yuebing Li ,
Irys Caristo ,
Debbie Hastings ,
John Anthony Morren ,
Michael Weiss ,
Srikanth Muppidi ,
Tia Nguyen ,
Lesly Welsh ,
Yuen So ,
Neelam Goyal ,
Michael Pulley ,
Cathy Bailey ,
Zubair Quraishi ,
Alan Berger ,
Gregory Sahagian ,
Yasmin Camberos ,
Benjamin Frishberg
July 2021
July 2021
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p class="first" id="d4318791e285">There is an unmet need for treatment options for
generalised myasthenia gravis that
are effective, targeted, well tolerated, and can be used in a broad population of
patients. We aimed to assess the safety and efficacy of efgartigimod (ARGX-113), a
human IgG1 antibody Fc fragment engineered to reduce pathogenic IgG autoantibody levels,
in patients with generalised myasthenia gravis.
</p>