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The far-reaching scope of neuroinflammation after traumatic brain injury
Dennis W. Simon ,
Mandy J. McGeachy ,
Hülya Bayır ,
Robert S. B. Clark ,
David J. Loane ,
Patrick M. Kochanek
February 10 2017
February 10 2017
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Abstract
Neuroinflammation can cause acute secondary injury after traumatic brain injury (TBI), and has been linked to chronic neurodegenerative diseases; however, anti-inflammatory agents have failed to improve TBI outcomes in clinical trials. In this Review, the authors propose a new framework for targeted immunomodulation after TBI.