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      Local Application of Adenosine Induces an Increase of Capillary Diameter in Skeletal Muscle of Anesthetized Rabbits

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          Abstract

          The effects of locally applied adenosine (ADO) and/or femoral artery pressure reduction (induced by complete aorta occlusion) on capillary diameter were investigated in the tenuissimus muscle of anesthetized rabbits. Capillaries were visualized by means of intravital video microscopy. Diameters were measured using an image shearing device. During control femoral artery pressure (median: 83 mm Hg) and without ADO, median capillary diameter was 4.3 µm (range: 3.2–5.3 µm; 27 capillaries in 7 animals). Complete aorta occlusion (median femoral artery pressure: 18 mm Hg) resulted in a reduction of capillary diameter to 3.9 µm (2.7–4.7 µm; p < 0.0001). Subsequent reactive hyperemia resulted in an increase in diameter to 5.2 µm (3.7–6.0 µm; p < 0.0001). Locally applied ADO (10-<sup>4</sup> M) probably led to complete vasodilation of the arterioles, because their diameters did not further increase during reactive hyperemia after complete occlusion. ADO (10∼<sup>4</sup>M) induced an increase of control capillary diameter to 5.5 µm (4.1–6.4 µm; median relative increase: 27%; p < 0.0001), resulting in a decrease of capillary resistance by 61 %. In the presence of ADO, aorta occlusion resulted in a capillary diameter decrease to 4.7 µm (3.4–6.1 µm; p < 0.0001). Subsequent reactive hyperemia resulted in an increase to maximally 5.6 µm (4.3–6.4 µm; p < 0.0001). This diameter was approximately the same as the control diameter during ADO. During occlusion in the presence of ADO, capillary diameter was significantly larger (11%; p < 0.0001) than during control without ADO. The capillary diameter changes induced by the various interventions were mainly passive, i.e., proportional to capillary transmural pressure changes. However, capillary diameter was larger during aorta occlusion in the presence of ADO than during control femoral artery pressures without ADO, even though capillary pressure was probably higher in the latter case. It is proposed that the prolonged increase in transmural capillary pressure due to ADO may induce changes in capillary wall configuration, leading to larger diameters.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1996
          1996
          24 September 2008
          : 33
          : 2
          : 111-118
          Affiliations
          Departments of aBiophysics, and bPhysiology, Cardiovascular Research Institute Maastricht, University of Limburg, Maastricht, The Netherlands
          Article
          159138 J Vasc Res 1996;33:111–118
          10.1159/000159138
          8630343
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Research Paper

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