93
views
0
recommends
+1 Recommend
0 collections
    8
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The role of Atg proteins in autophagosome formation.

      Annual review of cell and developmental biology

      Animals, Autophagy, physiology, Cell Membrane, metabolism, ultrastructure, Endoplasmic Reticulum, Fungal Proteins, genetics, Golgi Apparatus, Mitochondria, Multiprotein Complexes, chemistry, Phagosomes, Phosphatidylinositol 3-Kinases, Yeasts, cytology

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane reorganization. Since the discovery of yeast Atg-related proteins, autophagosome formation has been dissected at the molecular level. In this review we describe the molecular mechanism of autophagosome formation with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagosome membrane.

          Related collections

          Author and article information

          Journal
          21801009
          10.1146/annurev-cellbio-092910-154005

          Comments

          Comment on this article