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      Dynamics of problem setting and framing in citizen discussions on synthetic biology

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          Abstract

          Synthetic biology is an emerging scientific field where engineers and biologists design and build biological systems for various applications. Developing synthetic biology responsibly in the public interest necessitates a meaningful societal dialogue. In this article, we argue that facilitating such a dialogue requires an understanding of how people make sense of synthetic biology. We performed qualitative research to unravel the underlying dynamics of problem setting and framing in citizen discussions on synthetic biology. We found that most people are not inherently for or against synthetic biology as a technology or development in itself, but that their perspectives are framed by core values about our relationships with science and technology and that sensemaking is much dependent on the context and general feelings of (dis)content. Given that there are many assumptions focused on a more binary idea of the public’s view, we emphasize the need for frame awareness and understanding in a meaningful dialogue.

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          Most cited references41

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          Synthetic biology: applications come of age

          Key Points Early synthetic biology designs, namely the genetic toggle switch and repressilator, showed that regulatory components can be characterized and assembled to bring about complex, electronics-inspired behaviours in living systems (for example, memory storage and timekeeping). Through the characterization and assembly of genetic parts and biological building blocks, many more devices have been constructed, including switches, memory elements, oscillators, pulse generators, digital logic gates, filters and communication modules. Advances in the field are now allowing expansion beyond small gene networks to the realm of larger biological programs, which hold promise for a wide range of applications, including biosensing, therapeutics and the production of biofuels, pharmaceuticals and biomaterials. Synthetic biosensing circuits consist of sensitive elements that bind analytes and transducer modules that mobilize cellular responses. Balancing these two modules involves engineering modularity and specificity into the various circuits. Biosensor sensitive elements include environment-responsive promoters (transcriptional), RNA aptamers (translational) and protein receptors (post-translational). Biosensor transducer modules include engineered gene networks (transcriptional), non-coding regulatory RNAs (translational) and protein signal-transduction circuits (post-translational). The contributions of synthetic biology to therapeutics include: engineered networks and organisms for disease-mechanism elucidation, drug-target identification, drug-discovery platforms, therapeutic treatment, therapeutic delivery, and drug production and access. In the microbial production of biofuels and pharmaceuticals, synthetic biology has supplemented traditional genetic and metabolic engineering efforts by aiding the construction of optimized biosynthetic pathways. Optimizing metabolic flux through biosynthetic pathways is traditionally accomplished by driving the expression of pathway enzymes with strong, inducible promoters. New synthetic approaches include the rapid diversification of various pathway components, the rational and model-guided assembly of pathway components, and hybrid solutions.
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            The core of ‘design thinking’ and its application

            Kees Dorst (2011)
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              Public engagement coming of age: From theory to practice in STS encounters with nanotechnology

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                Author and article information

                Journal
                Public Underst Sci
                Public Underst Sci
                PUS
                sppus
                Public Understanding of Science (Bristol, England)
                SAGE Publications (Sage UK: London, England )
                0963-6625
                1361-6609
                09 June 2017
                April 2018
                : 27
                : 3
                : 294-309
                Affiliations
                [1-0963662517712207]VU University Amsterdam, The Netherlands
                Author notes
                [*]Afke Wieke Betten, Athena Institute, Faculty of Earth and Life Sciences, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands. Email: a.w.betten@ 123456vu.nl
                Article
                10.1177_0963662517712207
                10.1177/0963662517712207
                5843019
                28597721
                1f85261b-d174-43e5-9b45-84367499fbf1
                © The Author(s) 2017

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( http://www.uk.sagepub.com/aboutus/openaccess.htm).

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                Categories
                Articles

                Sociology
                complex problems,focus group methodology,framing,problem setting,public engagement,responsible research and innovation,synthetic biology

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