For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
36
views
141
references
 Top references
cited by
44
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
3 collections
    0
    shares
      237
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Backgroud

          The association between underlying comorbidities and cardiac injury and the prognosis in coronavirus disease 2019 (COVID‐19) patients was assessed in this study.

          Hypothesis

          The underlying comorbidities and cardiac injury may be associated with the prognosis in COVID‐19 patients.

          Methods

          A systematic search was conducted in PubMed, EMBASE, Web of science, and The Cochrane library from December 2019 to July 2020. The odds ratio (OR) and 95% confidence intervals (95% CI) were used to estimate the probability of comorbidities and cardiac injury in COVID‐19 patients with or without severe type, or in survivors vs nonsurvivors of COVID‐19 patients.

          Results

          A total of 124 studies were included in this analysis. A higher risk for severity was observed in COVID‐19 patients with comorbidities. The pooled result in patients with hypertension (OR 2.57, 95% CI: 2.12‐3.11), diabetes (OR 2.54, 95% CI: 1.89‐3.41), cardiovascular diseases (OR 3.86, 95% CI: 2.70‐5.52), chronic obstractive pulmonary disease (OR 2.71, 95% CI: 1.98‐3.70), chronic kidney disease (OR 2.20, 95% CI: 1.27‐3.80), and cancer (OR 2.42, 95% CI: 1.81‐3.22) respectively. All the comorbidities presented a higher risk of mortality. Moreover, the prevalence of acute cardiac injury is higher in severe group than in nonsevere group, and acute cardiac injury is associated with an increased risk for in‐hospital mortality.

          Conclusion

          Comorbidities and acute cardiac injury are closely associated with poor prognosis in COVID‐19 patients. It is necessary to continuously monitor related clinical indicators of organs injury and concern comorbidities in COVID‐19 patients.

          Related collections

          Most cited references141

          • Record: found
          • Abstract: found
          • Article: not found

          Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

          Xiaobo Yang, Yuan Yu, Jiqian Xu … (2020)
          Summary Background An ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus 2 (SARS-CoV-2) started in December, 2019, in Wuhan, China. Information about critically ill patients with SARS-CoV-2 infection is scarce. We aimed to describe the clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia. Methods In this single-centered, retrospective, observational study, we enrolled 52 critically ill adult patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital (Wuhan, China) between late December, 2019, and Jan 26, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were all collected. Data were compared between survivors and non-survivors. The primary outcome was 28-day mortality, as of Feb 9, 2020. Secondary outcomes included incidence of SARS-CoV-2-related acute respiratory distress syndrome (ARDS) and the proportion of patients requiring mechanical ventilation. Findings Of 710 patients with SARS-CoV-2 pneumonia, 52 critically ill adult patients were included. The mean age of the 52 patients was 59·7 (SD 13·3) years, 35 (67%) were men, 21 (40%) had chronic illness, 51 (98%) had fever. 32 (61·5%) patients had died at 28 days, and the median duration from admission to the intensive care unit (ICU) to death was 7 (IQR 3–11) days for non-survivors. Compared with survivors, non-survivors were older (64·6 years [11·2] vs 51·9 years [12·9]), more likely to develop ARDS (26 [81%] patients vs 9 [45%] patients), and more likely to receive mechanical ventilation (30 [94%] patients vs 7 [35%] patients), either invasively or non-invasively. Most patients had organ function damage, including 35 (67%) with ARDS, 15 (29%) with acute kidney injury, 12 (23%) with cardiac injury, 15 (29%) with liver dysfunction, and one (2%) with pneumothorax. 37 (71%) patients required mechanical ventilation. Hospital-acquired infection occurred in seven (13·5%) patients. Interpretation The mortality of critically ill patients with SARS-CoV-2 pneumonia is considerable. The survival time of the non-survivors is likely to be within 1–2 weeks after ICU admission. Older patients (>65 years) with comorbidities and ARDS are at increased risk of death. The severity of SARS-CoV-2 pneumonia poses great strain on critical care resources in hospitals, especially if they are not adequately staffed or resourced. Funding None.
          Article 0 comments Cited 4814 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

            Chaomin Wu, Xiaoyan Chen, Yanping Cai … (2020)
            Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated.
            Article 0 comments Cited 3567 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

              Ling Mao, Huijuan Jin, Mengdie Wang … (2020)
              The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, is serious and has the potential to become an epidemic worldwide. Several studies have described typical clinical manifestations including fever, cough, diarrhea, and fatigue. However, to our knowledge, it has not been reported that patients with COVID-19 had any neurologic manifestations.
              Article 0 comments Cited 3122 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Ling Tu: lingtu@tjh.tjmu.edu.cn
                Xizhen Xu:
                ORCID: https://orcid.org/0000-0002-9041-720X
                xzxu@tjh.tjmu.edu.cn
                Journal
                Journal ID (nlm-ta): Clin Cardiol
                Journal ID (iso-abbrev): Clin Cardiol
                Journal ID (doi): 10.1002/(ISSN)1932-8737
                Journal ID (publisher-id): CLC
                Title: Clinical Cardiology
                Publisher: Wiley Periodicals, Inc. (New York )
                ISSN (Print): 0160-9289
                ISSN (Electronic): 1932-8737
                Publication date (Electronic): 07 October 2020
                Electronic Location Identifier: 10.1002/clc.23465
                Affiliations
                [ 1 ] Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China
                [ 2 ] Division of Cardiology and Department of Internal Medicine, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
                [ 3 ] Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China
                [ 4 ] Division of Endocrinology and Department of Internal Medicine, Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China
                [ 5 ] Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China
                Author notes
                [*] [* ] Correspondence

                Dr Xizhen Xu, Division of Cardiology and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; No. 1095, Jiefang Avenue, Wuhan, Hubei 430030, China.

                Email: xzxu@ 123456tjh.tjmu.edu.cn

                Dr Ling Tu, Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, Hubei 430030, China.

                Email: lingtu@ 123456tjh.tjmu.edu.cn

                Author information
                https://orcid.org/0000-0003-2368-6896
                https://orcid.org/0000-0002-9041-720X
                Article
                Publisher ID: CLC23465
                DOI: 10.1002/clc.23465
                PMC ID: 7675427
                PubMed ID: 33026120
                SO-VID: 1f9cdb8e-fefd-49d9-9c3b-1785355a4966
                Copyright statement: © 2020 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 17 June 2020
                Date revision received : 05 September 2020
                Date accepted : 07 September 2020
                Page count
                Figures: 4, Tables: 0, Pages: 16, Words: 8567
                Product
                Categories
                Subject: Clinical Investigations
                Subject: Clinical Investigations
                Custom metadata
                source-schema-version-number 2.0
                edited-state corrected-proof
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.4 mode:remove_FC converted:19.11.2020

                ScienceOpen disciplines: Cardiovascular Medicine
                Keywords: cardiac injury,comorbidities,covid‐19,meta‐analysis,mortality,severity
                Data availability:
                ScienceOpen disciplines: Cardiovascular Medicine
                Keywords: cardiac injury, comorbidities, covid‐19, meta‐analysis, mortality, severity

                Comments

                Comment on this article

                scite_

                Similar content237

                See all similar

                Cited by42

                See all cited by

                Most referenced authors6,414

                See all reference authors