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      Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve.

      Nature

      Animals, Culture Techniques, Dinoprostone, Fibroblast Growth Factors, pharmacology, Fibroblasts, physiology, Gene Expression Regulation, drug effects, Immunologic Techniques, Interleukin-1, Macrophages, Nerve Growth Factors, biosynthesis, genetics, Nerve Regeneration, Platelet-Derived Growth Factor, Prostaglandins E, RNA, Messenger, metabolism, Rats, Schwann Cells, Sciatic Nerve, Tumor Necrosis Factor-alpha

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          Abstract

          The Schwann cells and fibroblast-like cells of the intact sciatic nerve of adult rats synthesize very little nerve growth factor (NGF). After lesion, however, there is a dramatic increase in the amounts of both NGF-mRNA and NGF protein synthesized by the sciatic non-neuronal cells. This local increase in NGF synthesis partially replaces the interrupted NGF supply from the periphery to the NGF-responsive sensory and sympathetic neurons, whose axons run within the sciatic nerve. Macrophages, known to invade the site of nerve lesion during wallerian degeneration, are important in the regulation of NGF synthesis. Here we demonstrate that the effect of macrophages on NGF-mRNA levels in cultured explants of sciatic nerve can be mimicked by conditioned media of activated macrophages, and that interleukin-1 is the responsible agent.

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          Journal
          3317065
          10.1038/330658a0

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