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      Nomifensine Test Does Not Differentiate Hyperprolactinemia Associated with and without Radiologic Abnormalities in the Sella turcica

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          A group of 17 hyperprolactinemic women was given 200 mg of nomifensine orally to evaluate its diagnostic potential to discriminate between tumors and nontu-morous hyperprolactinemia. The nomifensine suppressive effect on prolactin serum levels was not significantly different between patients with or without enlargement of the sella turcica. A control group of 5 women with normal prolactin levels exhibited a nomifensine suppressive effect below 65% of the baseline prolactin level, which was significantly different from that in the hyperprolactinemic group. In conclusion it is confirmed that the nomifensine test provides no value in the early diagnosis of the prolactinoma.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 15
          : 4
          : 213-217
          Department of Endocrinology, Hospital Gineco-Obstetricia No. 4, Instituto Mexicano del Seguro Social, Mexico
          179458 Horm Res 1981;15:213–217
          © 1981 S. Karger AG, Basel

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          Pages: 5
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