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      Similar efficacy of ciclesonide once daily versus fluticasone propionate twice daily in patients with persistent asthma.

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          Abstract

          This 12-week, double-blind, parallel-group study compared the efficacy and safety of once daily ciclesonide and twice daily fluticasone propionate in patients aged 12-75 years with persistent asthma. Patients were randomized to once-daily ciclesonide 80 micro g (n = 278) or 160 micro g (n = 271), or twice daily fluticasone propionate 88 micro g (n = 259) (all ex-actuator). Significant improvements from baseline were seen in all three treatment groups for forced expiratory volume in 1 second, asthma symptom scores and rescue medication use (all p < 0.0001). Asthma exacerbation rates were low (each ciclesonide group, n = 2; fluticasone group, n = 1). Adverse event reporting indicated good tolerability. Once daily ciclesonide 80 micro g or 160 micro g showed comparable efficacy and tolerability to twice daily fluticasone propionate 88 micro g in persistent asthma.

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          Author and article information

          Journal
          J Asthma
          The Journal of asthma : official journal of the Association for the Care of Asthma
          0277-0903
          0277-0903
          Sep 2007
          : 44
          : 7
          Affiliations
          [1 ] Center for Pneumology and Thoracic Surgery, Pulmonary Research Institute, Hospital Grosshansdorf, Grosshansdorf, Germany. magnussen@pulmoresearch.de
          Article
          782173844
          10.1080/02770900701537081
          17885859
          1fab2c0a-7cfe-4862-92c8-aa70df3f46f0
          History

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