A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

Abstract

A pair of new tirucallane triterpenoid epimers, picraquassins M and N ( 1 and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria ( Staphylococcus. aureus 209P and Escherichia coli ATCC0111) and two fungi ( Candida albicans FIM709 and Aspergillus niger R330) were evaluated.

Journal

Journal ID (publisher-id): CJNM

Title: Chinese Journal of Natural Medicines

Publisher: Elsevier BV

ISSN (Electronic): 1875-5364

Publication date (Electronic): 20 December 2019

Volume: 17

Issue: 12

Pages: 906-911

Affiliations

¹ College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

² Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China

Author notes

*Corresponding author: YAO Xin-Sheng, E-mails: tyaoxs@ 123456jnu.edu.cn ; GAO Hao, tghao@ 123456jnu.edu.cn

^Δ These authors contribute equally to this work.

These authors have no conflict of interest to declare.

Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

Article

Publisher ID: S1875-5364(19)30111-6

DOI: 10.1016/S1875-5364(19)30111-6

Copyright statement: Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

Funding

Funded by: National Key Research and Development Program of China

Award ID: 2018YFA0903200

Funded by: National Key Research and Development Program of China

Award ID: 2018YFA0903201

Funded by: National Natural Science Foundation of China

Award ID: 31761143016

Funded by: Chang Jiang Scholars Program

Award ID: GAO Hao, 2017

Funded by: Ministry of Education of China, National High-level Personnel of Special Support Program

Award ID: 2017RA2259

Funded by: Guangdong Special Support Program

Award ID: 2016TX03R280

Funded by: Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine

Award ID: QNRC2-B06

Funded by: Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme

Award ID: GAO Hao, 2014

Funded by: Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program

Award ID: 2017BT01Y036

Funded by: K. C. Wong Education Foundation

Award ID: GAO Hao, 2016

This work was supported by grants from the National Key Research and Development Program of China (Nos. 2018YFA0903200 and 2018YFA0903201), the National Natural Science Foundation of China (No. 31761143016), Chang Jiang Scholars Program (GAO Hao, 2017) from the Ministry of Education of China, National High-level Personnel of Special Support Program (No. 2017RA2259), Guangdong Special Support Program (No. 2016TX03R280), Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine (No. QNRC2-B06), Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (GAO Hao, 2014), Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (No. 2017BT01Y036), and K. C. Wong Education Foundation (GAO Hao, 2016).

Categories

Subject: Research article