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      A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

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          Abstract

          A pair of new tirucallane triterpenoid epimers, picraquassins M and N ( 1 and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria ( Staphylococcus. aureus 209P and Escherichia coli ATCC0111) and two fungi ( Candida albicans FIM709 and Aspergillus niger R330) were evaluated.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 906-911
          Affiliations
          1 College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
          2 Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
          Author notes
          *Corresponding author: YAO Xin-Sheng, E-mails: tyaoxs@ 123456jnu.edu.cn ; GAO Hao, tghao@ 123456jnu.edu.cn

          Δ These authors contribute equally to this work.

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30111-6
          10.1016/S1875-5364(19)30111-6
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Key Research and Development Program of China
          Award ID: 2018YFA0903200
          Funded by: National Key Research and Development Program of China
          Award ID: 2018YFA0903201
          Funded by: National Natural Science Foundation of China
          Award ID: 31761143016
          Funded by: Chang Jiang Scholars Program
          Award ID: GAO Hao, 2017
          Funded by: Ministry of Education of China, National High-level Personnel of Special Support Program
          Award ID: 2017RA2259
          Funded by: Guangdong Special Support Program
          Award ID: 2016TX03R280
          Funded by: Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine
          Award ID: QNRC2-B06
          Funded by: Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
          Award ID: GAO Hao, 2014
          Funded by: Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program
          Award ID: 2017BT01Y036
          Funded by: K. C. Wong Education Foundation
          Award ID: GAO Hao, 2016
          This work was supported by grants from the National Key Research and Development Program of China (Nos. 2018YFA0903200 and 2018YFA0903201), the National Natural Science Foundation of China (No. 31761143016), Chang Jiang Scholars Program (GAO Hao, 2017) from the Ministry of Education of China, National High-level Personnel of Special Support Program (No. 2017RA2259), Guangdong Special Support Program (No. 2016TX03R280), Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine (No. QNRC2-B06), Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (GAO Hao, 2014), Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (No. 2017BT01Y036), and K. C. Wong Education Foundation (GAO Hao, 2016).
          Categories
          Research article

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