Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention

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Abstract

The role of the apolipoprotein E (APOE) ε4 allele as an effect modifier in lifestyle interventions to prevent cognitive impairment is still unclear.

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Journal

Title: JAMA Neurology

Abbreviated Title: JAMA Neurol

Publisher: American Medical Association (AMA)

ISSN (Print): 2168-6149

Publication date Created: April 01 2018

Publication date (Print): April 01 2018

Volume: 75

Issue: 4

Page: 462

Affiliations

[1 ]Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland

[2 ]Aging Research Center, Karolinska Institutet, Stockholm University, Stockholm, Sweden

[3 ]Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden

[4 ]Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland

[5 ]Institute of Health Sciences/Geriatrics, University of Oulu and Oulu University Hospital, Oulu, Finland

[6 ]Medical Research Center Oulu, Oulu University Hospital and Oulu City Hospital, Oulu, Finland

[7 ]Department of Neurology, Kuopio University Hospital, Kuopio, Finland

[8 ]Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

[9 ]Hospital District of North Karelia, Joensuu, Finland

[10 ]Department of Public Health, Faculty of Medicine, University of Helsinki, Helskinki, Finland

[11 ]Finnish Institute of Occupational Health, Helsinki, Finland

[12 ]Welfare and Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland

[13 ]Department of Social and Psychological Studies, Karlstad University, Karlstad, Sweden

[14 ]Department of Psychology, Umeå University, Umeå, Sweden

[15 ]Department of Medicine, Geriatric Clinic, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

[16 ]Department of Public Health, University of Helsinki, Helsinki, Finland

[17 ]South Ostrobothnia Central Hospital, Seinäjoki, Finland

[18 ]Department of Neurosciences and Preventive Medicine, Danube-University Krems, Krems, Austria

[19 ]Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia

[20 ]Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, United Kingdom

Article

DOI: 10.1001/jamaneurol.2017.4365

PMC ID: 5885273

PubMed ID: 29356827

SO-VID: 1fbc9ce8-514a-4a4f-9627-e247174e7379

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Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention : A Subgroup Analysis of a Randomized Clinical Trial

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