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      Quantification of Myocardial Perfusion with MRI and Exogenous Contrast Agents

      a , a , a , b

      Cardiology

      S. Karger AG

      Myocardium, Perfusion, MRI contrast, Media model

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          Abstract

          This review discusses the applications of MRI to quantification of the myocardial perfusion. The first step of the measurement is to obtain a concentration-time curve from a signal intensity-time (SI) curve. Factors which influence the correlation between SI and the concentration are discussed for relaxivity and susceptibility agents. The second stage of measurement is to extract parameters of myocardial perfusion from the concentration-time curve. Two methods are considered, one for an intravascular agent and the other for an extravascular agent. Key points are illustrated with experimental data.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1997
          1997
          19 November 2008
          : 88
          : 1
          : 90-105
          Affiliations
          aCenter of Advanced Magnetic Resonance Development, and bDivision of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, N.C., USA
          Article
          177315 Cardiology 1997;88:90–105
          10.1159/000177315
          8960631
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 16
          Categories
          Myocardial Blood Flow Symposium

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