0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Eculizumab therapy in gemcitabine-induced thrombotic microangiopathy in a renal transplant recipient

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A renal transplant recipient 7 years post-transplantation, diagnosed with locally advanced pancreatic adenocarcinoma developed thrombotic microangiopathy (TMA) after treatment with gemcitabine and nab-paclitaxel. Gemcitabine was the most likely cause for TMA and was ceased. He received methylprednisolone and plasma exchange with fresh frozen plasma and albumin. Despite plasma exchange, his renal allograft function worsened, and he had persistent haematological evidence of haemolysis. Eculizumab was commenced with resolution-significant improvement in his renal and haematological markers. This case highlights an unusual occurrence of progressive gemcitabine-induced TMA in a renal allograft that had an excellent response to eculizumab. The clinical response also demonstrates involvement of complement dysregulation in gemcitabine-induced TNA.

          Related collections

          Author and article information

          Journal
          Oxf Med Case Reports
          Oxf Med Case Reports
          omcr
          Oxford Medical Case Reports
          Oxford University Press
          2053-8855
          June 2019
          14 June 2019
          : 2019
          : 6
          Affiliations
          [1 ]Department of Nephrology, St Vincent’s Hospital Melbourne, Fitzroy 3065 Victoria, Australia
          [2 ]Olivia-Newton John Cancer, Wellness and Research Centre, Austin Hospital, Heidelberg, Australia
          Author notes
          Correspondence address: St Vincent’s Hospital Melbourne, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia. Phone: 9231 2211; Fax: 9231 3151; E-mail: kngu.martin@ 123456gmail.com
          Article
          PMC6568204 PMC6568204 6568204 omz048
          10.1093/omcr/omz048
          6568204
          31214360
          © The Author(s) 2019. Published by Oxford University Press.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

          This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

          Page count
          Pages: 05
          Categories
          Case Report

          Comments

          Comment on this article