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Fibrinogen but not factor XIII deficiency is associated with bleeding after craniotomy.

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      Abstract

      Postoperative haemorrhage in neurosurgery is associated with significant morbidity and mortality. There is controversy whether or not factor XIII (FXIII) deficiency leads to bleeding complications after craniotomy. Decreased fibrinogen levels have been associated with an increased incidence of bleeding complications in cardiac and orthopaedic surgery. The aim of this study was to assess perioperative fibrinogen and FXIII levels in patients undergoing elective intracranial surgery with and without severe bleeding events.

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      Affiliations
      [1 ] Department of Anesthesiology, General Intensive Care and Pain Control and.
      [2 ] Department of Anesthesiology and Intensive Care, Landes-Nervenklinik Wagner-Jauregg, Linz, Austria.
      [3 ] Section for Medical Statistics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
      [4 ] Department of Anaesthetics and Intensive Care, Evangelical Hospital Vienna, Vienna, Austria.
      [5 ] Department of Anesthesiology, General Intensive Care and Pain Control and eva.schaden@meduniwien.ac.at.
      Journal
      Br J Anaesth
      British journal of anaesthesia
      1471-6771
      0007-0912
      Oct 2014
      : 113
      : 4
      24871873
      aeu133
      10.1093/bja/aeu133
      © The Author 2014. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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