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      Highly oxygenous trichilin-type limonoids from Trichilia sinensis

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          Abstract

          Six new trichilin-type limonoids ( 16) with C-19/29 lactol or acetal bridge and a new ring intact limonoid ( 7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including 1H NMR, 13C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B (SRB) method. Compound 7 showed weak inhibitory activity in Hela cell line at 40 μmol·L −1.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 912-917
          Affiliations
          1 Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
          Author notes
          *Corresponding author: KONG Ling-Yi, Tel/Fax: 86-25-83271405, E-mail: cpu_lykong@ 123456126.com ; LUO Jun, Tel/Fax: 86-25-83271402, E-mail: luojun@ 123456cpu.edu.cn

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30112-8
          10.1016/S1875-5364(19)30112-8
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 31470416
          Funded by: Outstanding Youth Fund of the Basic Research Program of Jiangsu Province
          Award ID: BK20160077
          Funded by: Program for Changjiang Scholars and Innovative Research Team in University
          Award ID: IRT_15R63
          This work was supported by the National Natural Science Foundation of China (No. 31470416), the Outstanding Youth Fund of the Basic Research Program of Jiangsu Province (No. BK20160077), and the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT_15R63).
          Categories
          Research article

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