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      Periurethral adenocarcinoma of mesonephric origin: A case report and review of the literature

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          Abstract

          Periurethral mesonephric adenocarcinoma is a rare tumor. To the best of our knowledge, only 13 cases have been reported in the literature to date. We report the case of a 36-year-old lady who presented with periurethral mesonephric adenocarcinoma, treated by surgery followed by adjuvant chemotherapy and pelvic radiotherapy. We demonstrate the unusual histology of mesonephric adenocarcinoma and the necessity to consider this tumor in the differential diagnosis of all unusual genito-urologic tumours. In the present literature, combination of surgery followed by chemotherapy and radiotherapy is the most suitable treatment for locally advanced periurethral mesonephric adenocarcinoma.

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          Mesonephric adenocarcinoma of the vagina

          Background Mesonephric adenocarcinoma of the vagina is an extremely rare tumor of the female genital tract, with only a few cases reported so far worldwide. Consequently, there is no established standard treatment and limited knowledge about the prognosis and biologic behavior of vaginal mesonephric adenocarcinoma. Methods This report documents a new case of vaginal mesonephric adenocarcinoma diagnosed in a 54-year-old woman, and analyzes this in the context of all previously published cases. Results MRI demonstrated that the 2.5 × 1.8 cm tumor of the vaginal wall was invading urethra and bladder. Following surgical excision, histologic analysis determined mesonephric adenocarcinoma of the vagina, stage pT2 R1. In order to avoid the mutilating extended surgery which would be required to reach R0 and considerable impairment of quality of life, adjuvant radiochemotherapy was administered with external radiation and brachytherapy, including 5 cycles of cisplatin (40 mg/m²) for radiosensitization. After 4 years of continuous oncologic follow-up, the patient is alive and clinically free of disease. Conclusion In this case it was shown that adjuvant radiochemotherapy with radiation and brachytherapy was effective to manage the surgical R1 situation and maintain the patient’s life quality. More published cases reports are needed to gradually substantiate optimal treatment strategies.
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            PRIMARY CARCINOMA OF THE URETHRA1

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              Primary carcinoma of the vagina. An analysis of 68 cases.

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                Author and article information

                Contributors
                Journal
                Urol Case Rep
                Urol Case Rep
                Urology Case Reports
                Elsevier
                2214-4420
                07 June 2018
                September 2018
                07 June 2018
                : 20
                : 25-27
                Affiliations
                [a ]Department of Surgery, Division of Urology, King Hussein Cancer Center, Jordan
                [b ]Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, Jordan
                [c ]Department of Gynecology and Oncology, King Hussein Cancer Center, Jordan
                Author notes
                []Corresponding author.Urologic Oncology & Robotic Surgery Consultant, Surgery Department, King Hussein Cancer Center, P.O. Box 1269 Al-Jubeiha, Amman, 11941, Jordan. aa.11119@ 123456khcc.jo
                Article
                S2214-4420(18)30097-4
                10.1016/j.eucr.2018.06.005
                6031865
                201ebcbb-30c3-4875-b909-575cbccfcda2
                © 2018 Published by Elsevier Inc.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 18 March 2018
                : 25 May 2018
                : 5 June 2018
                Categories
                Oncology

                mesonephric,adenocarcinoma,periurethral,radical cystectomy

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