Nephrotic Syndrome due to Immunologically Mediated Hypocomplementic Glomerulonephritis in a Patient of Waldenström’s Macroglobulinemia

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Abstract

A 72-year-old man was diagnosed as having nephritic syndrome complicated by Waldenström’s macroglobulinemia (WM). A monoclonal IgM lamda protein and decreased serum complements were observed. The renal biopsy disclosed the capillary occluded by thrombi which was stained with IgG, IgA, IgM, C4, lamda light chain and slight kappa light chain in a granular pattern. Electron dense deposits were noted in the subendothelial spaces. An unusual case of WM who developed nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis is described.

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Waldenström's macroglobulinemia with generalized amyloidosis.

James J Squires, Frederick H. Sheldon, B M Forget (1966)

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 2002

Publication date (Print): October 2002

Publication date (Electronic): 02 September 2002

Volume: 92

Issue: 2

Pages: 452-455

Affiliations

Departments of ^aInternal Medicine, and ^bPathology, Saga Medical School, Nabeshima, Saga, Japan

Article

Publisher ID: 63286 Other ID: Nephron 2002;92:452–455

DOI: 10.1159/000063286

PubMed ID: 12218329

SO-VID: 2020dc45-1a44-4425-abe6-1e4ada8d4d86

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 21 November 2001

Page count

Figures: 4, References: 13, Pages: 4

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