- Record: found
- Abstract: found
- Article: found
Effects of COVID-19 Outbreak on Children’s Mental Health: A Comparative Study with Children Diagnosed and Isolated from Their Parents
research-article
Author(s):
Şenay Kılınçel
1 ,
Feray Tarımtay Altun
2 ,
Özgecan Nuryüz
3 ,
Ezgi Tan
4 ,
Erkal Erzincan
5 ,
Oğuzhan Kılınçel
6 ,
Esra Yazıcı
7 ,
Muhammed Ayaz
3
Publication date (Electronic):
22 February 2021
Journal:
Psychiatry Investigation
Publisher:
Korean Neuropsychiatric Association
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Objective
The COVID-19 outbreak has negatively affected children in many ways. This study aimed to compare the psychological responses of children exposed to different levels of stress during the COVID-19 outbreak.
Methods
The anxiety levels, negative thoughts, and quality of life of COVID-19-positive children with COVID-19-positive parents (Child+ group, n=17), COVID-19-negative children who are separated from COVID-19-positive parents (Parent+ group, n=59), and a control group (n=64) were compared. The participants completed the Screen for Child Anxiety and Related Disorders (SCARED), Children’s Negative Cognitive Errors Questionnaire (CNCEQ), and Pediatric Quality of Life Inventory (PedsQL).
Results
The statistical analysis revealed that the Parent+ group recorded higher SCARED and CNCEQ scores and lower PedsQL scores in comparison with the control group. No statistically significant difference was found between the scores of the Child+ and control groups. Furthermore, high CNCEQ scores and low PedsQL scores in the Parent+ group predicted an increase in their SCARED scores.
Related collections
Most cited references40
- Record: found
- Abstract: found
- Article: not found
The psychological impact of quarantine and how to reduce it: rapid review of the evidence
Summary The December, 2019 coronavirus disease outbreak has seen many countries ask people who have potentially come into contact with the infection to isolate themselves at home or in a dedicated quarantine facility. Decisions on how to apply quarantine should be based on the best available evidence. We did a Review of the psychological impact of quarantine using three electronic databases. Of 3166 papers found, 24 are included in this Review. Most reviewed studies reported negative psychological effects including post-traumatic stress symptoms, confusion, and anger. Stressors included longer quarantine duration, infection fears, frustration, boredom, inadequate supplies, inadequate information, financial loss, and stigma. Some researchers have suggested long-lasting effects. In situations where quarantine is deemed necessary, officials should quarantine individuals for no longer than required, provide clear rationale for quarantine and information about protocols, and ensure sufficient supplies are provided. Appeals to altruism by reminding the public about the benefits of quarantine to wider society can be favourable.
- Record: found
- Abstract: found
- Article: not found
SARS Control and Psychological Effects of Quarantine, Toronto, Canada
Laura Hawryluck, Wayne Gold, Susan Robinson … (2004)
Severe acute respiratory syndrome (SARS) was contained globally by widespread quarantine measures, measures that had not been invoked to contain an infectious disease in North America for >50 years ( 1 – 6 ). Although quarantine has periodically been used for centuries to contain and control the spread of infectious diseases such as cholera and the plague with some success ( 1 – 4 , 6 – 8 ), the history of invoking quarantine measures is tarnished by threats, generalized fear, lack of understanding, discrimination, economic hardships, and rebellion ( 1 , 3 , 4 , 6 – 8 ). Quarantine separates persons who have been potentially exposed to an infectious agent (and thus at risk for disease) from the general community. For the greater public good, quarantine may create heavy psychological, emotional, and financial problems for some persons. To be effective, quarantine demands not only that at-risk persons be isolated but also that they follow appropriate infection control measures within their place of quarantine. Reporting on SARS quarantine has focused on ways in which quarantine was implemented and compliance was achieved ( 1 – 4 , 6 – 8 ). Adverse effects on quarantined persons and the ways in which those quarantined can best be supported have not been evaluated. Moreover, little is known about adherence to infection-control measures by persons in quarantine. Knowledge and understanding of the experiences of quarantined persons are critical to maximize infectious disease containment and minimize the negative effects on those quarantined, their families, and social networks. The objectives of our study were to assess the level of knowledge about quarantine and infection control measures of persons who were placed in quarantine, to explore ways by which these persons received information to evaluate the level of adherence to public health recommendations, and to understand the psychological effect on quarantined persons during the recent SARS outbreaks in Toronto, Canada. Methods Description of Quarantine in Toronto During the first and second SARS outbreaks in Toronto, >15,000 persons with an epidemiologic exposure to SARS were instructed to remain in voluntary quarantine (Health Canada, unpub. data). Data on the demographics of the quarantined population were collected, but have not yet been analyzed (B. Henry, Toronto Public Health, pers. comm.). Quarantined persons were instructed not to leave their homes or have visitors. They were told to wash their hands frequently, to wear masks when in the same room as other household members, not to share personal items (e.g., towels, drinking cups, or cutlery), and to sleep in separate rooms. In addition, they were instructed to measure their temperature twice daily. If any symptoms of SARS developed, they were to call Toronto Public Health or Telehealth Ontario for instructions ( 5 ). Study Population All persons who were placed in quarantine during the SARS outbreaks in Toronto (at least 15,000 persons) were eligible for participation in this study. The survey was announced through media releases, including locally televised interviews with the principal investigators. Information on the study and invitations to participate were posted in local healthcare institutions, libraries, and supermarkets. Ethics approval was obtained from the research ethics board of the University Health Network, a teaching institution affiliated with the University of Toronto. Survey Instrument A Web-based survey composed of 152 multiple choice and short- answer questions was to be completed after participants ended their period of quarantine. It took approximately 20 minutes to complete. Questions explored included the following: 1) knowledge and understanding of the reasons for quarantine ( 2 ), knowledge of and adherence to infection control directives, and ( 3 ) source of this knowledge. The psychological impact of quarantine was evaluated with validated scales, including the Impact of Event Scale—Revised (IES-R) ( 9 ) and the Center for Epidemiologic Studies—Depression Scale (CES-D) ( 10 ). The IES-R is a self-report measure designed to assess current subjective distress resulting from a traumatic life event and is composed of 22 items, each with a Likert rating scale from 0 to 4. The maximum score is 88. In a study of journalists working in war zones, the mean IES-R score of posttraumatic stress disorder (PTSD) was 20. In these persons, the presence of PTSD symptoms, as measured by this scale, was correlated with diagnostic psychiatric interviews ( 11 ). The CES-D is a measure of depressive symptoms composed of 20 self-report items, each with a Likert rating scale from 0 to 3. The maximum score is 60 ( 10 ). A score of> 16 has been shown to identify persons with depressive symptoms similar in severity to the levels observed among depressed patients ( 10 , 12 , 13 ). Open-ended questions provided respondents with the opportunity to relate the aspects of quarantine that were most difficult for them and allowed them to provide additional comments on their unique experiences. Statistical Analysis Means were calculated to summarize continuous variables. For categorical variables, group proportions were calculated. Student t tests were used to examine relationships between demographic variables and the psychological outcome variables, the scores on the IES-R and CES-D. A score of >20 on the IES-R was used to estimate the prevalence of PTSD symptoms ( 11 ). A score of >16 on the CES-D was used to estimate the prevalence of depressive symptoms ( 10 , 12 , 13 ). Analysis of variance (ANOVA), chi-square, and the Cochran-Armitage test for trend were used to examine relations between the IES-R and CES-D scores and the following independent variables: healthcare worker status, home or work quarantine, acquaintance of or direct exposure to someone with a diagnosis of SARS, combined annual household income, and the frequency with which persons placed in quarantine wore their masks. Linear regression for the trends between income categories and both PTSD and depressive symptoms was analyzed. The relationships between the IES-R and CES-D and whether persons in quarantine wore their masks all of the time versus never were examined by the Duncan-Waller K-ratio t tests. A p value of $75,000 (Canadian dollars [CAD]). Figure Number of persons in quarantine, Toronto, Canada, February 23–June 30, 2003. Figure courtesy of Toronto Public Health. The 129 respondents described 143 periods of quarantine with 90% of respondents being placed into quarantine only once; 66% of respondents were on home quarantine, while 34% were on work quarantine. The median duration of quarantine was 10 days (interquartile range 8–10 days). Half of respondents knew someone who was hospitalized with SARS of whom 77% were colleagues; 10% knew someone who had died of SARS (Table 1). Table 1 Characteristics of quarantined persons who responded to the survey Characteristic No. (%) N=129 Age (y) 18–25 11 (8.6) 26–35 37 (28.9) 36–45 44 (34.4) 46–55 21 (16.4) 56–65 11 (8.7) 66+ 4 (3.1) Marital status Married or common law 87 (68.0) Single or divorced 41 (32.0) Education High school 11 (9.2) College or university 109 (90.8) Income (Canadian $) $100,000 36 (34.0) Healthcare worker status No 40 (31.8) Yes 86 (68.3) Type of quarantine
(N = 143 episodes) Work 49 (34.3) Home 94 (65.7) Household members No. adults 1 28 (21.9) 2 72 (56.4) 3 22 (17.2) 4 5 (3.9) >5 1 (0.8) No. children 0 72 (55.8) 1 24 (18.6) 2 25 (19.4) 3 8 (6.2) Persons were notified of their need to go into quarantine from the following sources: their workplace (58%), the media (27%), their healthcare provider (7%), and public health officials (9%). Most (68%) understood that they were quarantined to prevent them from transmitting infection to others; 8.5% of respondents believed they were quarantined to protect themselves from infection; 15% did not believe they should have been placed into quarantine at all; and 8.5% provided more than one of these responses. The source of notification for quarantine influenced understanding of the reason for quarantine. Those who were notified by the media or their workplace were more likely to understand the reason for quarantine than those who were notified by their healthcare provider or public health unit (p = 0.04). Healthcare workers were also more likely to understand the reason for quarantine compared with non–healthcare workers, 76.5% versus 52.5% (p = 0.007). Combined household income and level of education did not influence understanding of the reason for quarantine. Information on Infection Control Measures Persons received their information regarding infection control measures to be adhered to during their quarantine from the following sources: the media (54%), public health authorities (52%), occupational health department (33%), healthcare providers (29%), word-of-mouth (23%), hospital Web sites (21%), and other Web sites (40%). Those who did not think they had been well-informed were angry that information on infection control measures and quarantine was inconsistent and incomplete, frustrated that employers (healthcare institutions) and public health officials were difficult to contact, disappointed that they did not receive the support they expected, and anxious about the lack of information on the modes of transmission and prognosis of SARS (Appendix). During the outbreaks, nearly 30% of respondents thought that they had received inadequate information about SARS. With respect to information regarding home infection control measures, 20% were not told with whom they could have contact; 29% did not receive specific instructions on when to change their masks; and 40%–50% did not receive instructions on the use and disinfection of personal items, including toothbrushes and cutlery; 77% were not given instructions regarding use and disinfection of the telephone. Healthcare worker status did not influence whether respondents thought they had received adequate information regarding any of the listed home infection control measures, except regarding the frequency of mask changing: healthcare workers more frequently reported that they had received adequate information, 78.8% versus 60.5% (p = 0.03). Adherence to Infection Control Measures Eighty-five percent of quarantined persons wore a mask in the presence of household members; 58% remained inside their residence for the duration of their quarantine. Thirty-three percent of those quarantined did not monitor their temperatures as recommended: 26% self-monitored their temperatures less frequently than recommended, and 7% did not measure their temperatures at all. No differences between healthcare workers and nonhealthcare workers were found with respect to adherence to recommended infection control measures. Psychological Impact of Quarantine The mean IES-R score was 15.2±17.8, and the mean CES-D was 13.0±11.6. The IES-R score was >20 for 28.9%; the CES-D score was >16 in 31.2% of quarantined persons (Table 2). The mean IES-R scores were not different for persons on home or work quarantine, 14.1±18.8 versus 17.6±16.6 (p = 0.33); the mean CES-D scores were also not different between the groups, 12.0±12.0 versus 15.2±10.7 (p = 0.16). Table 2 Prevalence of posttraumatic stress disorder and depressive symptoms according to patient demographicsa Characteristic No. (%) N=129 Prevalence CES-D 16 38 (31.2) IES-R 20 35 (28.9) Marital status Mean SD p value CES-D Single or divorced (n = 40) 12.9 10.7 0.85 Married (n = 79) 12.5 11.4 IES-R Single or divorced (n = 39) 14.5 16.6 0.82 Married (n = 79) 13.8 14.6 Income (Canadian $) CES-D $75,000 10.9 9.2 IES-R $75,000 11.8 11.6 Duration of quarantine (d) CES-D 10 17.0 14.2 IES-R 10 23.7 27.2 aCES-D, Center for Epidemiologic Studies—Depression Scale ( 10 ); IES-R,Impact of Event Scale—Revised ( 9 ).
bBy analysis of variance. The presence of PTSD symptoms was correlated with the presence of depressive symptoms (p $75,000 was associated with increased PTSD symptoms (mean IES-R score of 24.2±20.6 versus 20.0±24.4 versus 11.8±11.6, respectively) (p = 0.03 for the three-way comparison). Linear regression testing for trend over income categories was also significant (p = 0.01). A combined annual household income of CAD $75,000 was also associated with increased depressive symptoms (mean CES-D score of 18.3±15.4 versus 15.5±13.2 versus 10.9±9.2, respectively) (p = 0.05 for the three-way comparison) (Table 2). Results of linear regression testing for trend over income categories were also significant (p = 0.01). Neither age, level of education, healthcare worker status, living with other adult household members, nor having children was correlated with PTSD and depressive symptoms. The duration of quarantine was significantly related to increased PTSD symptoms, mean IES-R score of 23.7±27.2 for those in quarantine >10 days compared with 11.7±10.7 for those in quarantine 10 days versus 11.2±10.1 for those in quarantine 20 on the IES-R was used to estimate the prevalence of PTSD symptoms in our study population. This corresponds to the mean score measured on the IES-R in a study of journalists working in war zones that used diagnostic psychiatric interviews to confirm the presence of this disorder ( 11 ). Since most respondents to our survey were healthcare workers, we chose a work-related traumatic event for the comparison group. While other cutoff points may have been used to estimate the prevalence of PTSD symptoms in our population, the risk factors that we identified for increased PTSD symptoms, rather than the absolute prevalence of PTSD in our study participants, are the important findings of this study. This also applies to the risk factors that we identified for increased depressive symptoms in the respondents. Quarantined persons with risk factors for either PTSD or depressive symptoms may benefit from increased support from public health officials. In this population, the presence of PTSD symptoms was highly correlated with the presence of depressive symptoms even though different clinical symptoms characterize the two disorders. Kessler's National Comorbidity Study indicated a 48.2% occurrence of depression in patients with PTSD ( 15 ). PTSD is an anxiety disorder characterized by avoiding stimuli associated with a traumatic event, reexperiencing the trauma, and hyperarousal, such as increased vigilance ( 16 ). This disorder may develop after exposure to traumatic events that involve a life-threatening component, and a person's vulnerability to the development of PTSD can be increased if the trauma is perceived to be a personal assault ( 17 ). Increased length of time spent in quarantine was associated with increased symptoms of PTSD. This finding might suggest that quarantine itself, independent of acquaintance with or exposure to someone with SARS, may be perceived as a personalized trauma. The presence of more PTSD symptoms in persons with an acquaintance or exposure to someone with a diagnosis of SARS compared to persons who did not have this personal connection may indicate a greater perceived self-risk. The small number of respondents who were acquainted with or exposed to someone who died of SARS may explain the lack of correlation between this group and greater PTSD and depressive symptoms (44 persons died of SARS in the greater Toronto area). This study also notes the trend toward increasing symptoms of both PTSD and depression as the combined annual income of the respondent household fell from CAD >$75,000 to CAD 50% of the respondents reported a combined annual household income of CAD >$75,000. As many as 50% of respondents felt that they had not received adequate information regarding at least one aspect of home infection control, and not all of the respondents adhered to recommendations. Why some infection control measures were adhered to while others were not is unclear. A combination of lack of knowledge, an incomplete understanding of the rationale for these measures, and a lack of reinforcement from an overwhelmed public health system were likely contributors to this problem. Of particular interest, strictly adhering to infection control measures, including wearing masks more frequently than recommended, was associated with increased levels of distress. Whether persons with higher baseline levels of distress were more likely to strictly adhere to infection-control measures or whether adherence to recommended infection-control strategies resulted in developing higher levels of distress cannot be clarified without interviewing the respondents. Regardless of the cause, this distress may have been lessened with enhanced education and continued reinforcement of the rationale for these measures and outreach efforts to optimize coping with the stressful event. This study has several limitations. The actual number of respondents is low compared to the total number of persons who were placed into quarantine and therefore may not be representative of the entire group of quarantined persons. However, lack of funding, confidentiality of public health records, and an overloaded public health response system limited sampling in this study. Furthermore, a self-selection effect may have occurred with those persons who were experiencing the greatest or least levels of distress responding to the survey. In addition, respondents required access to a computer to respond, which suggests that they may be more educated and have higher socioeconomic status than the overall group who were quarantined. They also had to be English speaking. Recognizing these limitations, however, an anonymous Web-based method was chosen because concerns about persons' confidentiality precluded us from access to their public health records. A Web-based format was chosen over random-digit dialing for both cost considerations and time constraints. The project was initiated and completed without a funding source soon after the outbreak period at a time when concerns about SARS were still a part of daily life in Toronto. Obtaining as much information about the adverse effects of quarantine as close to the event as possible was important because a study conducted several months later would have been subject to the limitations of substantial recall bias. If this study were to be repeated, a study design ensuring a more representative selection of the population that used a combination of quantitative and qualitative methods, including structured diagnostic interviews, would be recommended to overcome these concerns. In the event of future outbreaks, a matched control group of persons who were not quarantined should be considered because it would allow an assessment of the distress experienced by the community at large. Finally, we determined only the prevalence of symptoms of PTSD and depression in our study population because these were the predominant psychological distresses that were observed to be emerging in our SARS patient population (W.L.G., pers. comm.). We also focused on symptoms of PTSD and depression because we believed that they would be the most likely to cause illness and interfere with long-term functioning. Future studies should assess persons for other psychological responses, including fear, anger, guilt, and stigmatization. A standardized survey instrument that considers the full spectrum of psychological responses to quarantine should be developed. In the event of future outbreaks in which quarantine measures are implemented, a standardized instrument would enable a comparison between the psychological responses to outbreaks of different infectious causes and could be used to monitor symptoms over time. Despite these limitations, the results of this survey allow for the generation of hypotheses that require further exploration. Our data show that quarantine can result in considerable psychological distress in the forms of PTSD and depressive symptoms. Public health officials, infectious diseases physicians, and psychiatrists and psychologists need to be made aware of this issue. They must work to define the factors that influence the success of quarantine and infection control practices for both disease containment and community recovery and must be prepared to offer additional support to persons who are at increased risk for the adverse psychological and social consequences of quarantine. Appendix Comments from survey respondents Unmet informational needs: 1. Public health /employers: a. Difficulty in access: "Called Public Health for 2 days. Got through 3 times; waited on hold for hours, then got hung up on." (respondent # 131) b. Failed expectations: "I was expecting someone from Public Health to check up on me but never got a call except on my last day of quarantine." (respondent #126); "Nobody told me anything. I was not contacted by health officials at all." (respondent# 99); "My employer should have been more forthcoming." (respondent #7); "I was not called by the hospital I worked at. I saw the quarantine on the news and spent a whole day trying to get through to my unit." (respondent #40) c. Lack of support: "I was looking for more support from the health care professionals. They left me in the dark to deal with this." (respondent #22) 2. Nature of information: a. Details re: infection control: "I have since learned that there are a lot of precautions that no one ever told me about." (respondent #81) b. Inconsistencies: "Information was not always the same. Many inconsistencies." (respondent #66) c. Timing: "Information was given too late, as I started 1 week after exposure. Unacceptable!" (respondent #27) d. Specific issues: i. Children: "Nobody can tell me exactly where my children would be arranged to go in case I got SARS myself. I was very panicked at that time and my husband was admitted that time because of the SARS." (respondent # 78) ii. Onset of symptoms: "What symptoms were considered serious and what to do when I experienced those symptoms." (respondent # 21); "I was mildly alarmed to realize that I didn't know what to do if I actually did develop symptoms of SARS." (respondent # 111) iii. Prognosis of SARS: "Most of the really important info is largely unknown" (respondent #53); "Prognosis for SARS, how many have recovered, what health problems recovered patients still have." (respondent #8I) iv. Mode of transmission: "If airborne what were the chances of contracting the disease… MD unable to answer." (respondent #90)
- Record: found
- Abstract: found
- Article: not found
Covid-19 — Navigating the Uncharted
Anthony Fauci, H. Lane, Robert Redfield (2020)
The latest threat to global health is the ongoing outbreak of the respiratory disease that was recently given the name Coronavirus Disease 2019 (Covid-19). Covid-19 was recognized in December 2019. 1 It was rapidly shown to be caused by a novel coronavirus that is structurally related to the virus that causes severe acute respiratory syndrome (SARS). As in two preceding instances of emergence of coronavirus disease in the past 18 years 2 — SARS (2002 and 2003) and Middle East respiratory syndrome (MERS) (2012 to the present) — the Covid-19 outbreak has posed critical challenges for the public health, research, and medical communities. In their Journal article, Li and colleagues 3 provide a detailed clinical and epidemiologic description of the first 425 cases reported in the epicenter of the outbreak: the city of Wuhan in Hubei province, China. Although this information is critical in informing the appropriate response to this outbreak, as the authors point out, the study faces the limitation associated with reporting in real time the evolution of an emerging pathogen in its earliest stages. Nonetheless, a degree of clarity is emerging from this report. The median age of the patients was 59 years, with higher morbidity and mortality among the elderly and among those with coexisting conditions (similar to the situation with influenza); 56% of the patients were male. Of note, there were no cases in children younger than 15 years of age. Either children are less likely to become infected, which would have important epidemiologic implications, or their symptoms were so mild that their infection escaped detection, which has implications for the size of the denominator of total community infections. On the basis of a case definition requiring a diagnosis of pneumonia, the currently reported case fatality rate is approximately 2%. 4 In another article in the Journal, Guan et al. 5 report mortality of 1.4% among 1099 patients with laboratory-confirmed Covid-19; these patients had a wide spectrum of disease severity. If one assumes that the number of asymptomatic or minimally symptomatic cases is several times as high as the number of reported cases, the case fatality rate may be considerably less than 1%. This suggests that the overall clinical consequences of Covid-19 may ultimately be more akin to those of a severe seasonal influenza (which has a case fatality rate of approximately 0.1%) or a pandemic influenza (similar to those in 1957 and 1968) rather than a disease similar to SARS or MERS, which have had case fatality rates of 9 to 10% and 36%, respectively. 2 The efficiency of transmission for any respiratory virus has important implications for containment and mitigation strategies. The current study indicates an estimated basic reproduction number (R0) of 2.2, which means that, on average, each infected person spreads the infection to an additional two persons. As the authors note, until this number falls below 1.0, it is likely that the outbreak will continue to spread. Recent reports of high titers of virus in the oropharynx early in the course of disease arouse concern about increased infectivity during the period of minimal symptoms. 6,7 China, the United States, and several other countries have instituted temporary restrictions on travel with an eye toward slowing the spread of this new disease within China and throughout the rest of the world. The United States has seen a dramatic reduction in the number of travelers from China, especially from Hubei province. At least on a temporary basis, such restrictions may have helped slow the spread of the virus: whereas 78,191 laboratory-confirmed cases had been identified in China as of February 26, 2020, a total of 2918 cases had been confirmed in 37 other countries or territories. 4 As of February 26, 2020, there had been 14 cases detected in the United States involving travel to China or close contacts with travelers, 3 cases among U.S. citizens repatriated from China, and 42 cases among U.S. passengers repatriated from a cruise ship where the infection had spread. 8 However, given the efficiency of transmission as indicated in the current report, we should be prepared for Covid-19 to gain a foothold throughout the world, including in the United States. Community spread in the United States could require a shift from containment to mitigation strategies such as social distancing in order to reduce transmission. Such strategies could include isolating ill persons (including voluntary isolation at home), school closures, and telecommuting where possible. 9 A robust research effort is currently under way to develop a vaccine against Covid-19. 10 We anticipate that the first candidates will enter phase 1 trials by early spring. Therapy currently consists of supportive care while a variety of investigational approaches are being explored. 11 Among these are the antiviral medication lopinavir–ritonavir, interferon-1β, the RNA polymerase inhibitor remdesivir, chloroquine, and a variety of traditional Chinese medicine products. 11 Once available, intravenous hyperimmune globulin from recovered persons and monoclonal antibodies may be attractive candidates to study in early intervention. Critical to moving the field forward, even in the context of an outbreak, is ensuring that investigational products are evaluated in scientifically and ethically sound studies. 12 Every outbreak provides an opportunity to gain important information, some of which is associated with a limited window of opportunity. For example, Li et al. report a mean interval of 9.1 to 12.5 days between the onset of illness and hospitalization. This finding of a delay in the progression to serious disease may be telling us something important about the pathogenesis of this new virus and may provide a unique window of opportunity for intervention. Achieving a better understanding of the pathogenesis of this disease will be invaluable in navigating our responses in this uncharted arena. Furthermore, genomic studies could delineate host factors that predispose persons to acquisition of infection and disease progression. The Covid-19 outbreak is a stark reminder of the ongoing challenge of emerging and reemerging infectious pathogens and the need for constant surveillance, prompt diagnosis, and robust research to understand the basic biology of new organisms and our susceptibilities to them, as well as to develop effective countermeasures.
Author and article information
Journal
Journal ID (nlm-ta): Psychiatry Investig
Journal ID (iso-abbrev): Psychiatry Investig
Journal ID (publisher-id): PI
Title:
Psychiatry Investigation
Publisher:
Korean Neuropsychiatric Association
ISSN
(Print):
1738-3684
ISSN
(Electronic):
1976-3026
Publication date
(Print):
February
2021
Publication date
(Electronic):
22
February
2021
Volume: 18
Issue: 2
Pages: 140-146
Affiliations
Author notes
Correspondence: Muhammed Ayaz, MD Mentalica Consultancy Education and Research Center,
Altayçeşme Mah. Öz Sokak, 19/5, 34843, Maltepe, İstanbul, Turkey Tel: +90 533 302
38 93, E-mail:
ayazmuhammed@
123456yahoo.com
Author information
Şenay Kılınçel
http://orcid.org/0000-0001-5298-0264
Feray Tarımtay Altun
http://orcid.org/0000-0003-3726-8169
Özgecan Nuryüz
http://orcid.org/0000-0002-4753-8823
Ezgi Tan
http://orcid.org/0000-0002-3548-4063
Erkal Erzincan
http://orcid.org/0000-0001-6586-4430
Oğuzhan Kılınçel
http://orcid.org/0000-0003-2988-4631
Esra Yazıcı
http://orcid.org/0000-0002-2575-7398
Muhammed Ayaz
http://orcid.org/0000-0002-9715-3809
Article
Publisher ID: pi-2020-0372DOI: 10.30773/pi.2020.0372
PMC ID: 7960744
PubMed ID: 33601873
SO-VID: 202c0826-af68-4479-9233-e6a9adb02087
Copyright © Copyright © 2021 Korean Neuropsychiatric Association
License:
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
History
Date
received
: 08
October
2020
Date
revision received
: 12
November
2020
Date
accepted
: 27
November
2020
Categories
Subject:
Original Article
ScienceOpen disciplines: Clinical Psychology & Psychiatry