We discuss several proposals for astrophysical and cosmological tests of quantum theory. The tests are motivated by deterministic hidden-variables theories, and in particular by the view that quantum physics is merely an effective theory of an equilibrium state. The proposed tests involve searching for nonequilibrium violations of quantum theory in: primordial inflaton fluctuations imprinted on the cosmic microwave background, relic cosmological particles, Hawking radiation, photons with entangled partners inside black holes, neutrino oscillations, and particles from very distant sources.