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      Regulation of Gene Expression by Fatty Acids and Fibric Acid Derivatives: An Integrative Role for Peroxisome Prolif erator Activated Receptors

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          Abstract

          A group of receptors termed peroxisome proliferator activated receptors (PPAR), belonging to the nuclear hormone receptor supergene family, might be crucial in explaining how a diverse group of apparently unrelated chemicals induce peroxisomal proliferation and a change in the expression of several genes. The activation of these PPAR by peroxisome proliferators, as well as by fatty acids, might reconcile the apparent discrepancy between the two prevailing theories that explain peroxisome proliferation, i.e. the receptor and the fatty acid theory. Although the exact physiological role of PPAR is not yet known, these receptors might have a far more general function than strictly regulating peroxisomal gene expression by changing the expression of numerous genes in response to developmental and nutritional challenges. Much work, however, remains to be performed before a complete picture will emerge.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-5815-0
          978-3-318-02120-2
          1663-2818
          1663-2826
          1992
          1992
          03 December 2008
          : 38
          : 5-6
          : 269-277
          Affiliations
          Laboratoire de Biologie des Régulations chez les Eucaryotes, Centre de Biochimie, UMR 134 du CNRS, Nice, France
          Article
          182557 Horm Res 1992;38:269–277
          10.1159/000182557
          1339170
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Original Paper

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