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      A Review of Pharmacological Treatments for Depression in Alzheimer's Disease.

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          Abstract

          Depression in Alzheimer's disease (dAD) is one of the most common behavioral and psychological symptoms of dementia, with devastating consequences not only for the affected individuals, but for caregivers as well. So far, pharmacological treatment of dAD has been based on the "monoamine hypothesis". However, the reported moderate effects of approved antidepressants, as well as an increasing body of research evidence, suggest a more complex pathophysiologic mechanism. In the present paper, a systematic review of different treatments for dAD is presented that can inform the study of alternative neuropathological and neurobiological aspects of the disease aimed at the development of more effective treatment targets.

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          Author and article information

          Journal
          J. Alzheimers Dis.
          Journal of Alzheimer's disease : JAD
          IOS Press
          1875-8908
          1387-2877
          2015
          : 48
          : 1
          Affiliations
          [1 ] Division of Geriatric Psychiatry, 1st Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
          [2 ] Department of Psychiatry and Behavioral Sciences, John's Hopkins University, School of Medicine, USA.
          Article
          JAD148010
          10.3233/JAD-148010
          26401925
          205dde97-10c5-4d4e-b256-6d127f333701
          History

          depression,treatment,Alzheimer’s disease,antidepressants,dementia

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