50
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The Fas death factor.

      Science (New York, N.Y.)

      Amino Acid Sequence, Animals, Antigens, CD95, Antigens, Surface, chemistry, genetics, physiology, Apoptosis, Autoimmune Diseases, immunology, Base Sequence, Cytotoxicity, Immunologic, Down-Regulation, Fas Ligand Protein, Humans, Lymphocyte Activation, Lymphocytes, cytology, Lymphoproliferative Disorders, Membrane Glycoproteins, Molecular Sequence Data, T-Lymphocytes, Cytotoxic

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.

          Related collections

          Author and article information

          Journal
          7533326

          Comments

          Comment on this article