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      Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.

      Science (New York, N.Y.)

      Receptors, Scavenger, metabolism, immunology, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Dendritic Cells, Antigens, Endocytosis, Endosomes, Histocompatibility Antigens Class II, Lectins, C-Type, Lymphocyte Activation, Lysosomes, Macrophages, Mannose-Binding Lectins, Mice, Mice, Inbred C57BL, Models, Immunological, Ovalbumin, Pinocytosis, Receptors, Cell Surface, Animals, Antigen Presentation

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          Abstract

          The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8+ effector T cells (cross-presentation) or to CD4+ T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation to CD8+ or CD4+ T cells. Specifically, the mannose receptor supplied an early endosomal compartment distinct from lysosomes, which was committed to cross-presentation. These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis.

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          Journal
          17463291
          10.1126/science.1137971

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